CRHR2

Protein identityUniProt · HPA

UniProt accession

Q13324

Gene

CRHR2

Ensembl

ENSG00000106113

Chromosome

7

Canonical length

411 aa

Protein class

G-protein coupled receptors, Predicted membrane proteins, Predicted secreted proteins

Subcellular location

Plasma membrane

Secretome location

Secreted - unknown location

OverviewNCBI Gene

The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011]

Canonical amino-acid sequenceUniProt

411 residues, UniProt reviewed canonical sequence.

>Q13324|CRHR2
     1  MDAALLHSLL EANCSLALAE ELLLDGWGPP LDPEGPYSYC NTTLDQIGTC WPRSAAGALV
    61  ERPCPEYFNG VKYNTTRNAY RECLENGTWA SKINYSQCEP ILDDKQRKYD LHYRIALVVN
   121  YLGHCVSVAA LVAAFLLFLA LRSIRCLRNV IHWNLITTFI LRNVMWFLLQ LVDHEVHESN
   181  EVWCRCITTI FNYFVVTNFF WMFVEGCYLH TAIVMTYSTE RLRKCLFLFI GWCIPFPIIV
   241  AWAIGKLYYE NEQCWFGKEP GDLVDYIYQG PIILVLLINF VFLFNIVRIL MTKLRASTTS
   301  ETIQYRKAVK ATLVLLPLLG ITYMLFFVNP GEDDLSQIMF IYFNSFLQSF QGFFVSVFYC
   361  FFNGEVRSAV RKRWHRWQDH HSLRVPMARA MSIPTSPTRI SFHSIKQTAA V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CRHR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

7

Mean surface accessibility (rSASA)

0.36

Highest tissue expression

21 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.28

gnomAD pLI

0

gnomAD missense Z

0.75

DepMap mean gene effect

0.12

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• adenylate cyclase-modulating G protein-coupled receptor signaling pathway
• cell surface receptor signaling pathway
• long-term synaptic potentiation

Molecular functions

• corticotrophin-releasing factor receptor activity
• corticotropin-releasing hormone receptor activity
• G protein-coupled peptide receptor activity
• peptide hormone binding

Cellular components

• axon terminus
• dendrite
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• GPCR, family 2, secretin-like
• GPCR, family 2, extracellular hormone receptor domain
• GPCR, family 2, corticotropin releasing factor receptor
• GPCR, family 2-like, 7TM
• GPCR, family 2, secretin-like, conserved site
• GPCR family 2, extracellular hormone receptor domain superfamily
• G-protein coupled receptor 2
• 7 transmembrane receptor (Secretin family)
• Hormone receptor domain
• GPCR, family 2, corticotropin releasing factor receptor, type 2

KeywordsUniProt

• Cell membrane
• Disulfide bond
• G-protein coupled receptor
• Glycoprotein
• Membrane
• Receptor
• Signal
• Transducer
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of CRHR2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• UCN