ADGRF4

Protein identityUniProt · HPA

UniProt accession

Q8IZF3

Gene

ADGRF4

Ensembl

ENSG00000153294

Chromosome

6

Canonical length

695 aa

Protein class

G-protein coupled receptors, Predicted membrane proteins

Subcellular location

Mitochondria

OverviewNCBI Gene

Sequence analysis of this gene suggests that it is encodes a member of the superfamily of G protein-couple receptors. G protein-coupled receptors typically contain seven hydrophobic transmembrane domains, interact with guanine nucleotide binding regulatory proteins, and detect molecules outside the cell and act to transduce these signals into intracellular responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2016]

Canonical amino-acid sequenceUniProt

695 residues, UniProt reviewed canonical sequence.

>Q8IZF3|ADGRF4
     1  MKMKSQATMI CCLVFFLSTE CSHYRSKIHL KAGDKLQSPE GKPKTGRIQE KCEGPCISSS
    61  NCSQPCAKDF HGEIGFTCNQ KKWQKSAETC TSLSVEKLFK DSTGASRLSV AAPSIPLHIL
   121  DFRAPETIES VAQGIRKNCP FDYACITDMV KSSETTSGNI AFIVELLKNI STDLSDNVTR
   181  EKMKSYSEVA NHILDTAAIS NWAFIPNKNA SSDLLQSVNL FARQLHIHNN SENIVNELFI
   241  QTKGFHINHN TSEKSLNFSM SMNNTTEDIL GMVQIPRQEL RKLWPNASQA ISIAFPTLGA
   301  ILREAHLQNV SLPRQVNGLV LSVVLPERLQ EIILTFEKIN KTRNARAQCV GWHSKKRRWD
   361  EKACQMMLDI RNEVKCRCNY TSVVMSFSIL MSSKSMTDKV LDYITCIGLS VSILSLVLCL
   421  IIEATVWSRV VVTEISYMRH VCIVNIAVSL LTANVWFIIG SHFNIKAQDY NMCVAVTFFS
   481  HFFYLSLFFW MLFKALLIIY GILVIFRRMM KSRMMVIGFA IGYGCPLIIA VTTVAITEPE
   541  KGYMRPEACW LNWDNTKALL AFAIPAFVIV AVNLIVVLVV AVNTQRPSIG SSKSQDVVII
   601  MRISKNVAIL TPLLGLTWGF GIATLIEGTS LTFHIIFALL NAFQGFFILL FGTIMDHKIR
   661  DALRMRMSSL KGKSRAAENA SLGPTNGSKL MNRQG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADGRF4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Unknown

Secreted

No

Transmembrane segments

7

Mean surface accessibility (rSASA)

0.32

Highest tissue expression

37 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.22

gnomAD pLI

0

DepMap mean gene effect

0.1

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• adenylate cyclase-activating G protein-coupled receptor signaling pathway
• cell surface receptor signaling pathway
• G protein-coupled receptor signaling pathway

Molecular functions

• G protein-coupled receptor activity

Cellular components

• membrane

Protein domainsUniProt · Pfam · InterPro

• GPS motif
• GPCR, family 2, secretin-like
• GPCR family 2, Ig-hepta-like receptor
• GPCR, family 2-like, 7TM
• GAIN domain superfamily
• Adhesion G-protein coupled receptor
• GAIN, subdomain B
• 7 transmembrane receptor (Secretin family)
• GPCR proteolysis site, GPS, motif

KeywordsUniProt

• Disulfide bond
• G-protein coupled receptor
• Glycoprotein
• Membrane
• Receptor
• Signal
• Transducer
• Transmembrane
• Transmembrane helix