Seroatlas · Human Serome Atlas

ADGRF3

Adhesion G-protein coupled receptor F3

Also known as: AGRF3_HUMAN, GPR113, hGPCR37, PGR23

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IZF5
Gene: ADGRF3
Ensembl: ENSG00000173567
Chromosome: 2
Canonical length: 1079 aa
Protein class: G-protein coupled receptors, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Golgi apparatus,Cytosol

OverviewNCBI Gene

Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1079 residues, UniProt reviewed canonical sequence.

>Q8IZF5|ADGRF3
     1  MVCSAAPLLL LATTLPLLGS PVAQASQPVS ETGVRPREGL QRRQWGPLIG RDKAWNERID
    61  RPFPACPIPL SSSFGRWPKG QTMWAQTSTL TLTEEELGQS QAGGESGSGQ LLDQENGAGE
   121  SALVSVYVHL DFPDKTWPPE LSRTLTLPAA SASSSPRPLL TGLRLTTECN VNHKGNFYCA
   181  CLSGYQWNTS ICLHYPPCQS LHNHQPCGCL VFSHPEPGYC QLLPPGSPVT CLPAVPGILN
   241  LNSQLQMPGD TLSLTLHLSQ EATNLSWFLR HPGSPSPILL QPGTQVSVTS SHGQAALSVS
   301  NMSHHWAGEY MSCFEAQGFK WNLYEVVRVP LKATDVARLP YQLSISCATS PGFQLSCCIP
   361  STNLAYTAAW SPGEGSKASS FNESGSQCFV LAVQRCPMAD TTYACDLQSL GLAPLRVPIS
   421  ITIIQDGDIT CPEDASVLTW NVTKAGHVAQ APCPESKRGI VRRLCGADGV WGPVHSSCTD
   481  ARLLALFTRT KLLQAGQGSP AEEVPQILAQ LPGQAAEASS PSDLLTLLST MKYVAKVVAE
   541  ARIQLDRRAL KNLLIATDKV LDMDTRSLWT LAQARKPWAG STLLLAVETL ACSLCPQDHP
   601  FAFSLPNVLL QSQLFGPTFP ADYSISFPTR PPLQAQIPRH SLAPLVRNGT EISITSLVLR
   661  KLDHLLPSNY GQGLGDSLYA TPGLVLVISI MAGDRAFSQG EVIMDFGNTD GSPHCVFWDH
   721  SLFQGRGGWS KEGCQAQVAS ASPTAQCLCQ HLTAFSVLMS PHTVPEEPAL ALLTQVGLGA
   781  SILALLVCLG VYWLVWRVVV RNKISYFRHA ALLNMVFCLL AADTCFLGAP FLSPGPRSPL
   841  CLAAAFLCHF LYLATFFWML AQALVLAHQL LFVFHQLAKH RVLPLMVLLG YLCPLGLAGV
   901  TLGLYLPQGQ YLREGECWLD GKGGALYTFV GPVLAIIGVN GLVLAMAMLK LLRPSLSEGP
   961  PAEKRQALLG VIKALLILTP IFGLTWGLGL ATLLEEVSTV PHYIFTILNT LQGVFILLFG
  1021  CLMDRKIQEA LRKRFCRAQA PSSTISLVSC CLQILSCASK SMSEGIPWPS SEDMGTARS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADGRF3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 0.9 nTPM

Expression across tissuesHPA

Tissue

kidney: 0.9 nTPM
pancreas: 0.9 nTPM
duodenum: 0.6 nTPM
salivary gland: 0.6 nTPM
testis: 0.5 nTPM
appendix: 0.4 nTPM

Single-cell type

cardiomyocytes: 107 nCPM
epicardial cells: 64 nCPM
late spermatids: 53 nCPM
early spermatids: 40 nCPM
late primary spermatocytes: 30 nCPM
tuft cells: 23 nCPM

Immune cell

eosinophil: 0.5 nTPM
T-reg: 0.5 nTPM
memory B-cell: 0.4 nTPM
naive CD8 T-cell: 0.4 nTPM
gdT-cell: 0.3 nTPM
memory CD8 T-cell: 0.3 nTPM

Brain region

cerebellum: 3 nTPM
cerebral cortex: 2.6 nTPM
medulla oblongata: 2.4 nTPM
white matter: 2.4 nTPM
amygdala: 2 nTPM
basal ganglia: 2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.14
gnomAD pLI: 0
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

G protein-coupled receptor activity

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

GPS motif
GPCR, family 2, secretin-like
GPCR, family 2, extracellular hormone receptor domain
GPCR, family 2-like, 7TM
GPCR, family 2, secretin-like, conserved site
GPCR family 2, extracellular hormone receptor domain superfamily
GAIN domain superfamily
Adhesion G-protein coupled receptor
GAIN, subdomain B
ADGRF3/5-like, N-terminal domain
7 transmembrane receptor (Secretin family)
GPCR proteolysis site, GPS, motif
Hormone receptor domain
ADGRF3-like, N-terminal domain
Adhesion G-protein coupled receptor F3, Ig-like domain
Adhesion G-protein coupled receptor F3-like, Ig-like domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADGRF3 as an antibody target. Whether an autoantibody or antibody against ADGRF3 could matter depends on whether native ADGRF3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADGRF3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ADGRF3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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