Seroatlas · Human Serome Atlas

VIPR2

Vasoactive intestinal polypeptide receptor 2

Also known as: VIPR2_HUMAN, VPAC2, VPAC2R

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P41587
Gene
VIPR2
Ensembl
ENSG00000106018
Chromosome
7
Canonical length
438 aa
Protein class
G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Focal adhesion sites

OverviewNCBI Gene

This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

438 residues, UniProt reviewed canonical sequence.

>P41587|VIPR2
     1  MRTLLPPALL TCWLLAPVNS IHPECRFHLE IQEEETKCAE LLRSQTEKHK ACSGVWDNIT
    61  CWRPANVGET VTVPCPKVFS NFYSKAGNIS KNCTSDGWSE TFPDFVDACG YSDPEDESKI
   121  TFYILVKAIY TLGYSVSLMS LATGSIILCL FRKLHCTRNY IHLNLFLSFI LRAISVLVKD
   181  DVLYSSSGTL HCPDQPSSWV GCKLSLVFLQ YCIMANFFWL LVEGLYLHTL LVAMLPPRRC
   241  FLAYLLIGWG LPTVCIGAWT AARLYLEDTG CWDTNDHSVP WWVIRIPILI SIIVNFVLFI
   301  SIIRILLQKL TSPDVGGNDQ SQYKRLAKST LLLIPLFGVH YMVFAVFPIS ISSKYQILFE
   361  LCLGSFQGLV VAVLYCFLNS EVQCELKRKW RSRCPTPSAS RDYRVCGSSF SRNGSEGALQ
   421  FHRGSRAQSF LQTETSVI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VIPR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
19 nTPM

Expression across tissuesHPA

Tissue

  • seminal vesicle: 19 nTPM
  • pancreas: 17 nTPM
  • heart muscle: 15 nTPM
  • cervix: 15 nTPM
  • blood vessel: 13 nTPM
  • colon: 13 nTPM

Single-cell type

  • mesothelial cells: 222 nCPM
  • pituicytes/fscs: 148 nCPM
  • cardiomyocytes: 132 nCPM
  • epicardial cells: 125 nCPM
  • müller glia: 106 nCPM
  • pancreatic acinar cells: 85 nCPM

Immune cell

  • plasmacytoid DC: 12 nTPM
  • memory CD8 T-cell: 0.7 nTPM
  • MAIT T-cell: 0.3 nTPM
  • gdT-cell: 0.2 nTPM
  • basophil: 0.1 nTPM
  • naive CD8 T-cell: 0.1 nTPM

Brain region

  • cerebral cortex: 17 nTPM
  • white matter: 7.6 nTPM
  • pons: 7.2 nTPM
  • medulla oblongata: 5.9 nTPM
  • amygdala: 5.8 nTPM
  • hypothalamus: 5.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.05
gnomAD pLI
0
gnomAD missense Z
0.28
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of VIPR2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VIPR2 as an antibody target. Whether an autoantibody or antibody against VIPR2 could matter depends on whether native VIPR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VIPR2 is annotated at the cell surface, where native VIPR2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label VIPR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/VIPR2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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