Seroatlas · Human Serome Atlas

ADGRA3

Adhesion G protein-coupled receptor A3

Also known as: AGRA3_HUMAN, FLJ38547, GPR125, PGR21

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IWK6
Gene
ADGRA3
Ensembl
ENSG00000152990
Chromosome
4
Canonical length
1321 aa
Protein class
G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins
Secretome location
Intracellular and membrane

OverviewNCBI Gene

This gene encodes a member of the G protein-coupled receptor superfamily. This membrane protein may play a role in tumor angiogenesis through its interaction with the human homolog of the Drosophila disc large tumor suppressor gene. This gene is mapped to a candidate region of chromosome 4 which may be associated with bipolar disorder and schizophrenia. [provided by RefSeq, Oct 2012]

Canonical amino-acid sequenceUniProt

1321 residues, UniProt reviewed canonical sequence.

>Q8IWK6|ADGRA3
     1  MEPPGRRRGR AQPPLLLPLS LLALLALLGG GGGGGAAALP AGCKHDGRPR GAGRAAGAAE
    61  GKVVCSSLEL AQVLPPDTLP NRTVTLILSN NKISELKNGS FSGLSLLERL DLRNNLISSI
   121  DPGAFWGLSS LKRLDLTNNR IGCLNADIFR GLTNLVRLNL SGNLFSSLSQ GTFDYLASLR
   181  SLEFQTEYLL CDCNILWMHR WVKEKNITVR DTRCVYPKSL QAQPVTGVKQ ELLTCDPPLE
   241  LPSFYMTPSH RQVVFEGDSL PFQCMASYID QDMQVLWYQD GRIVETDESQ GIFVEKNMIH
   301  NCSLIASALT ISNIQAGSTG NWGCHVQTKR GNNTRTVDIV VLESSAQYCP PERVVNNKGD
   361  FRWPRTLAGI TAYLQCTRNT HGSGIYPGNP QDERKAWRRC DRGGFWADDD YSRCQYANDV
   421  TRVLYMFNQM PLNLTNAVAT ARQLLAYTVE AANFSDKMDV IFVAEMIEKF GRFTKEEKSK
   481  ELGDVMVDIA SNIMLADERV LWLAQREAKA CSRIVQCLQR IATYRLAGGA HVYSTYSPNI
   541  ALEAYVIKST GFTGMTCTVF QKVAASDRTG LSDYGRRDPE GNLDKQLSFK CNVSNTFSSL
   601  ALKNTIVEAS IQLPPSLFSP KQKRELRPTD DSLYKLQLIA FRNGKLFPAT GNSTNLADDG
   661  KRRTVVTPVI LTKIDGVNVD THHIPVNVTL RRIAHGADAV AARWDFDLLN GQGGWKSDGC
   721  HILYSDENIT TIQCYSLSNY AVLMDLTGSE LYTQAASLLH PVVYTTAIIL LLCLLAVIVS
   781  YIYHHSLIRI SLKSWHMLVN LCFHIFLTCV VFVGGITQTR NASICQAVGI ILHYSTLATV
   841  LWVGVTARNI YKQVTKKAKR CQDPDEPPPP PRPMLRFYLI GGGIPIIVCG ITAAANIKNY
   901  GSRPNAPYCW MAWEPSLGAF YGPASFITFV NCMYFLSIFI QLKRHPERKY ELKEPTEEQQ
   961  RLAANENGEI NHQDSMSLSL ISTSALENEH TFHSQLLGAS LTLLLYVALW MFGALAVSLY
  1021  YPLDLVFSFV FGATSLSFSA FFVVHHCVNR EDVRLAWIMT CCPGRSSYSV QVNVQPPNSN
  1081  GTNGEAPKCP NSSAESSCTN KSASSFKNSS QGCKLTNLQA AAAQCHANSL PLNSTPQLDN
  1141  SLTEHSMDND IKMHVAPLEV QFRTNVHSSR HHKNRSKGHR ASRLTVLREY AYDVPTSVEG
  1201  SVQNGLPKSR LGNNEGHSRS RRAYLAYRER QYNPPQQDSS DACSTLPKSS RNFEKPVSTT
  1261  SKKDALRKPA VVELENQQKS YGLNLAIQNG PIKSNGQEGP LLGTDSTGNV RTGLWKHETT
  1321  V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADGRA3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
55 nTPM

Expression across tissuesHPA

Tissue

  • liver: 55 nTPM
  • choroid plexus: 24 nTPM
  • thyroid gland: 24 nTPM
  • fallopian tube: 20 nTPM
  • amygdala: 20 nTPM
  • basal ganglia: 19 nTPM

Single-cell type

  • pituitary stem cells: 665 nCPM
  • choroid plexus epithelial cells: 535 nCPM
  • thymic myoid cells: 378 nCPM
  • astrocytes: 374 nCPM
  • endometrial ciliated cells: 350 nCPM
  • hepatocytes: 345 nCPM

Immune cell

  • NK-cell: 0.6 nTPM
  • naive CD4 T-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • choroid plexus: 78 nTPM
  • midbrain: 59 nTPM
  • hypothalamus: 41 nTPM
  • spinal cord: 40 nTPM
  • thalamus: 37 nTPM
  • medulla oblongata: 36 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.36
gnomAD pLI
0.29
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADGRA3 as an antibody target. Whether an autoantibody or antibody against ADGRA3 could matter depends on whether native ADGRA3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADGRA3 is annotated at the cell surface, where native ADGRA3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ADGRA3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ADGRA3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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