Seroatlas · Human Serome Atlas

ADGRD1

Adhesion G-protein coupled receptor D1

Also known as: AGRD1_HUMAN, DKFZp434B1272, GPR133, PGR25

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6QNK2
Gene: ADGRD1
Ensembl: ENSG00000111452
Chromosome: 12
Canonical length: 874 aa
Protein class: G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Nuclear speckles,Plasma membrane

OverviewNCBI Gene

The adhesion G-protein-coupled receptors (GPCRs), including GPR133, are membrane-bound proteins with long N termini containing multiple domains. GPCRs, or GPRs, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins (summary by Bjarnadottir et al., 2004 [PubMed 15203201]).[supplied by OMIM, Nov 2010]

Canonical amino-acid sequenceUniProt

874 residues, UniProt reviewed canonical sequence.

>Q6QNK2|ADGRD1
     1  MEKLLRLCCW YSWLLLFYYN FQVRGVYSRS QDHPGFQVLA SASHYWPLEN VDGIHELQDT
    61  TGDIVEGKVN KGIYLKEEKG VTLLYYGRYN SSCISKPEQC GPEGVTFSFF WKTQGEQSRP
   121  IPSAYGGQVI SNGFKVCSSG GRGSVELYTR DNSMTWEASF SPPGPYWTHV LFTWKSKEGL
   181  KVYVNGTLST SDPSGKVSRD YGESNVNLVI GSEQDQAKCY ENGAFDEFII WERALTPDEI
   241  AMYFTAAIGK HALLSSTLPS LFMTSTASPV MPTDAYHPII TNLTEERKTF QSPGVILSYL
   301  QNVSLSLPSK SLSEQTALNL TKTFLKAVGE ILLLPGWIAL SEDSAVVLSL IDTIDTVMGH
   361  VSSNLHGSTP QVTVEGSSAM AEFSVAKILP KTVNSSHYRF PAHGQSFIQI PHEAFHRHAW
   421  STVVGLLYHS MHYYLNNIWP AHTKIAEAMH HQDCLLFATS HLISLEVSPP PTLSQNLSGS
   481  PLITVHLKHR LTRKQHSEAT NSSNRVFVYC AFLDFSSGEG VWSNHGCALT RGNLTYSVCR
   541  CTHLTNFAIL MQVVPLELAR GHQVALSSIS YVGCSLSVLC LVATLVTFAV LSSVSTIRNQ
   601  RYHIHANLSF AVLVAQVLLL ISFRLEPGTT PCQVMAVLLH YFFLSAFAWM LVEGLHLYSM
   661  VIKVFGSEDS KHRYYYGMGW GFPLLICIIS LSFAMDSYGT SNNCWLSLAS GAIWAFVAPA
   721  LFVIVVNIGI LIAVTRVISQ ISADNYKIHG DPSAFKLTAK AVAVLLPILG TSWVFGVLAV
   781  NGCAVVFQYM FATLNSLQGL FIFLFHCLLN SEVRAAFKHK TKVWSLTSSS ARTSNAKPFH
   841  SDLMNGTRPG MASTKLSPWD KSSHSAHRVD LSAV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADGRD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 55 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 55 nTPM
urinary bladder: 37 nTPM
lung: 31 nTPM
placenta: 24 nTPM
adipose tissue: 23 nTPM
stomach: 18 nTPM

Single-cell type

epicardial cells: 393 nCPM
mesothelial cells: 263 nCPM
cardiomyocytes: 196 nCPM
fibro-adipogenic progenitors: 142 nCPM
fibroblasts: 139 nCPM
endometrial stromal cells: 136 nCPM

Immune cell

intermediate monocyte: 2.3 nTPM
classical monocyte: 2 nTPM
non-classical monocyte: 1.9 nTPM
myeloid DC: 1.1 nTPM
total PBMC: 0.8 nTPM
NK-cell: 0.3 nTPM

Brain region

thalamus: 7.7 nTPM
hypothalamus: 7 nTPM
midbrain: 5.7 nTPM
cerebral cortex: 4.6 nTPM
pons: 4.5 nTPM
medulla oblongata: 4.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.81
gnomAD pLI: 0
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

G protein-coupled receptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ADGRD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ESYT1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADGRD1 as an antibody target. Whether an autoantibody or antibody against ADGRD1 could matter depends on whether native ADGRD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADGRD1 is annotated at the cell surface, where native ADGRD1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ADGRD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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