Seroatlas · Human Serome Atlas

ADGRG7

Adhesion G-protein coupled receptor G7

Also known as: AGRG7_HUMAN, FLJ14454, GPR128

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96K78
Gene: ADGRG7
Ensembl: ENSG00000144820
Chromosome: 3
Canonical length: 797 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins
Subcellular location: Plasma membrane

OverviewNCBI Gene

Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

797 residues, UniProt reviewed canonical sequence.

>Q96K78|ADGRG7
     1  MASCRAWNLR VLVAVVCGLL TGIILGLGIW RIVIRIQRGK STSSSSTPTE FCRNGGTWEN
    61  GRCICTEEWK GLRCTIANFC ENSTYMGFTF ARIPVGRYGP SLQTCGKDTP NAGNPMAVRL
   121  CSLSLYGEIE LQKVTIGNCN ENLETLEKQV KDVTAPLNNI SSEVQILTSD ANKLTAENIT
   181  SATRVVGQIF NTSRNASPEA KKVAIVTVSQ LLDASEDAFQ RVAATANDDA LTTLIEQMET
   241  YSLSLGNQSV VEPNIAIQSA NFSSENAVGP SNVRFSVQKG ASSSLVSSST FIHTNVDGLN
   301  PDAQTELQVL LNMTKNYTKT CGFVVYQNDK LFQSKTFTAK SDFSQKIISS KTDENEQDQS
   361  ASVDMVFSPK YNQKEFQLYS YACVYWNLSA KDWDTYGCQK DKGTDGFLRC RCNHTTNFAV
   421  LMTFKKDYQY PKSLDILSNV GCALSVTGLA LTVIFQIVTR KVRKTSVTWV LVNLCISMLI
   481  FNLLFVFGIE NSNKNLQTSD GDINNIDFDN NDIPRTDTIN IPNPMCTAIA ALLHYFLLVT
   541  FTWNALSAAQ LYYLLIRTMK PLPRHFILFI SLIGWGVPAI VVAITVGVIY SQNGNNPQWE
   601  LDYRQEKICW LAIPEPNGVI KSPLLWSFIV PVTIILISNV VMFITISIKV LWKNNQNLTS
   661  TKKVSSMKKI VSTLSVAVVF GITWILAYLM LVNDDSIRIV FSYIFCLFNT TQGLQIFILY
   721  TVRTKVFQSE ASKVLMLLSS IGRRKSLPSV TRPRLRVKMY NFLRSLPTLH ERFRLLETSP
   781  STEEITLSES DNAKESI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADGRG7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 40 nTPM

Expression across tissuesHPA

Tissue

duodenum: 40 nTPM
small intestine: 37 nTPM
liver: 23 nTPM
colon: 4.9 nTPM
rectum: 2.8 nTPM
bone marrow: 2 nTPM

Single-cell type

enterocytes: 136 nCPM
hepatocytes: 74 nCPM
goblet cells: 42 nCPM
paneth cells: 35 nCPM
enteric transient amplifying cells: 30 nCPM
gastric progenitor cells: 24 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.4 nTPM
cerebellum: 0.3 nTPM
basal ganglia: 0.2 nTPM
midbrain: 0.2 nTPM
thalamus: 0.2 nTPM
white matter: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.12
gnomAD pLI: 0
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

G protein-coupled receptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

GPS motif
GPCR, family 2, secretin-like
GPCR, family 2-like, 7TM
GAIN domain superfamily
GAIN, subdomain B
7 transmembrane receptor (Secretin family)
GPCR proteolysis site, GPS, motif
Orphan adhesion receptor GPR128, 7TM domain
Adhesion G-protein coupled receptor G7
GPR128, N-terminal domain
GPR128, GAIN subdomain A
GPR128, GAIN subdomain B
GPR128, N-terminal domain
GPR128, GAIN subdomain A
GPR128 GAIN subdomain B

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADGRG7 as an antibody target. Whether an autoantibody or antibody against ADGRG7 could matter depends on whether native ADGRG7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADGRG7 is annotated at the cell surface, where native ADGRG7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ADGRG7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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