Seroatlas · Human Serome Atlas

GPR157

G-protein coupled receptor 157

Also known as: FLJ12132, GP157_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5UAW9
Gene: GPR157
Ensembl: ENSG00000180758
Chromosome: 1
Canonical length: 335 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; phospholipase C-activating G protein-coupled receptor signaling pathway; and radial glial cell differentiation. Predicted to be located in ciliary membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

335 residues, UniProt reviewed canonical sequence.

>Q5UAW9|GPR157
     1  MQPSPPPTEL VPSERAVVLL SCALSALGSG LLVATHALWP DLRSRARRLL LFLSLADLLS
    61  AASYFYGVLQ NFAGPSWDCV LQGALSTFAN TSSFFWTVAI ALYLYLSIVR AARGPRTDRL
   121  LWAFHVVSWG VPLVITVAAV ALKKIGYDAS DVSVGWCWID LEAKDHVLWM LLTGKLWEML
   181  AYVLLPLLYL LVRKHINRAH TALSEYRPIL SQEHRLLRHS SMADKKLVLI PLIFIGLRVW
   241  STVRFVLTLC GSPAVQTPVL VVLHGIGNTF QGGANCIMFV LCTRAVRTRL FSLCCCCCSS
   301  QPPTKSPAGT PKAPAPSKPG ESQESQGTPG ELPST

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR157 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 56 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 56 nTPM
esophagus: 29 nTPM
tongue: 22 nTPM
skin: 22 nTPM
parathyroid gland: 14 nTPM
vagina: 13 nTPM

Single-cell type

esophageal apical cells: 220 nCPM
cdc: 201 nCPM
esophageal suprabasal cells: 133 nCPM
urothelial cells: 120 nCPM
myonuclei: 114 nCPM
syncytiotrophoblasts: 114 nCPM

Immune cell

neutrophil: 1.1 nTPM
basophil: 0.7 nTPM
gdT-cell: 0.6 nTPM
memory CD8 T-cell: 0.6 nTPM
MAIT T-cell: 0.5 nTPM
naive B-cell: 0.5 nTPM

Brain region

choroid plexus: 24 nTPM
medulla oblongata: 5.3 nTPM
hippocampal formation: 4.8 nTPM
pons: 4.4 nTPM
thalamus: 4.4 nTPM
cerebellum: 4.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.19
gnomAD pLI: 0
gnomAD missense Z: -0.06
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

G protein-coupled receptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

GPCR, family 2, secretin-like
GPCR, rhodopsin-like, 7TM
GPCR, family 2-like, 7TM
7 transmembrane receptor (Secretin family)
GCR1-cAMP receptor

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR157 as an antibody target. Whether an autoantibody or antibody against GPR157 could matter depends on whether native GPR157 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR157 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GPR157 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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