ADGRL3

Protein identityUniProt · HPA

UniProt accession

Q9HAR2

Gene

ADGRL3

Ensembl

ENSG00000150471

Chromosome

4

Canonical length

1447 aa

Protein class

G-protein coupled receptors, Plasma proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1447 residues, UniProt reviewed canonical sequence.

>Q9HAR2|ADGRL3
     1  MWPSQLLIFM MLLAPIIHAF SRAPIPMAVV RRELSCESYP IELRCPGTDV IMIESANYGR
    61  TDDKICDSDP AQMENIRCYL PDAYKIMSQR CNNRTQCAVV AGPDVFPDPC PGTYKYLEVQ
   121  YECVPYKVEQ KVFLCPGLLK GVYQSEHLFE SDHQSGAWCK DPLQASDKIY YMPWTPYRTD
   181  TLTEYSSKDD FIAGRPTTTY KLPHRVDGTG FVVYDGALFF NKERTRNIVK FDLRTRIKSG
   241  EAIIANANYH DTSPYRWGGK SDIDLAVDEN GLWVIYATEQ NNGKIVISQL NPYTLRIEGT
   301  WDTAYDKRSA SNAFMICGIL YVVKSVYEDD DNEATGNKID YIYNTDQSKD SLVDVPFPNS
   361  YQYIAAVDYN PRDNLLYVWN NYHVVKYSLD FGPLDSRSGQ AHHGQVSYIS PPIHLDSELE
   421  RPSVKDISTT GPLGMGSTTT STTLRTTTLS PGRSTTPSVS GRRNRSTSTP SPAVEVLDDM
   481  TTHLPSASSQ IPALEESCEA VEAREIMWFK TRQGQIAKQP CPAGTIGVST YLCLAPDGIW
   541  DPQGPDLSNC SSPWVNHITQ KLKSGETAAN IARELAEQTR NHLNAGDITY SVRAMDQLVG
   601  LLDVQLRNLT PGGKDSAARS LNKAMVETVN NLLQPQALNA WRDLTTSDQL RAATMLLHTV
   661  EESAFVLADN LLKTDIVREN TDNIKLEVAR LSTEGNLEDL KFPENMGHGS TIQLSANTLK
   721  QNGRNGEIRV AFVLYNNLGP YLSTENASMK LGTEALSTNH SVIVNSPVIT AAINKEFSNK
   781  VYLADPVVFT VKHIKQSEEN FNPNCSFWSY SKRTMTGYWS TQGCRLLTTN KTHTTCSCNH
   841  LTNFAVLMAH VEVKHSDAVH DLLLDVITWV GILLSLVCLL ICIFTFCFFR GLQSDRNTIH
   901  KNLCISLFVA ELLFLIGINR TDQPIACAVF AALLHFFFLA AFTWMFLEGV QLYIMLVEVF
   961  ESEHSRRKYF YLVGYGMPAL IVAVSAAVDY RSYGTDKVCW LRLDTYFIWS FIGPATLIIM
  1021  LNVIFLGIAL YKMFHHTAIL KPESGCLDNI KSWVIGAIAL LCLLGLTWAF GLMYINESTV
  1081  IMAYLFTIFN SLQGMFIFIF HCVLQKKVRK EYGKCLRTHC CSGKSTESSI GSGKTSGSRT
  1141  PGRYSTGSQS RIRRMWNDTV RKQSESSFIT GDINSSASLN REGLLNNARD TSVMDTLPLN
  1201  GNHGNSYSIA SGEYLSNCVQ IIDRGYNHNE TALEKKILKE LTSNYIPSYL NNHERSSEQN
  1261  RNLMNKLVNN LGSGREDDAI VLDDATSFNH EESLGLELIH EESDAPLLPP RVYSTENHQP
  1321  HHYTRRRIPQ DHSESFFPLL TNEHTEDLQS PHRDSLYTSM PTLAGVAATE SVTTSTQTEP
  1381  PPAKCGDAED VYYKSMPNLG SRNHVHQLHT YYQLGRGSSD GFIVPPNKDG TPPEGSSKGP
  1441  AHLVTSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADGRL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

7

Mean surface accessibility (rSASA)

0.4

Highest tissue expression

23 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.19

gnomAD pLI

1

DepMap mean gene effect

-0.09

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• adenylate cyclase-activating G protein-coupled receptor signaling pathway
• cell surface receptor signaling pathway
• cell-cell adhesion via plasma-membrane adhesion molecules
• excitatory synapse assembly
• G protein-coupled receptor signaling pathway
• neuron migration
• Rho-activating G protein-coupled receptor signaling pathway
• synapse assembly

Molecular functions

• calcium ion binding
• carbohydrate binding
• cell adhesion mediator activity
• G protein-coupled receptor activity
• molecular condensate scaffold activity

Cellular components

• axon
• cell-cell junction
• glutamatergic synapse
• membrane
• plasma membrane
• postsynaptic membrane

Protein domainsUniProt · Pfam · InterPro

• GPS motif
• GPCR, family 2, secretin-like
• D-galactoside/L-rhamnose binding SUEL lectin domain
• GPCR, family 2, extracellular hormone receptor domain
• Olfactomedin-like domain
• GPCR, family 2, latrophilin, C-terminal
• GPCR, family 2, latrophilin
• GPCR, family 2-like, 7TM
• GPCR, family 2, secretin-like, conserved site
• AGRL2-4 , GAIN subdomain A
• GPCR family 2, extracellular hormone receptor domain superfamily
• D-galactoside/L-rhamnose binding SUEL lectin domain superfamily
• GAIN domain superfamily
• GAIN, subdomain B
• 7 transmembrane receptor (Secretin family)
• GPCR proteolysis site, GPS, motif
• D-galactoside/L-rhamnose binding SUEL lectin domain
• Olfactomedin-like domain
• Latrophilin Cytoplasmic C-terminal region
• Hormone receptor domain
• AGRL2-4 GAIN subdomain A

KeywordsUniProt

• Calcium
• Cell junction
• Cell membrane
• Cell projection
• Disulfide bond
• G-protein coupled receptor
• Glycoprotein
• Lectin
• Membrane
• Metal-binding
• Phosphoprotein
• Postsynaptic cell membrane
• Receptor
• Signal
• Synapse
• Transducer
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of ADGRL3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• DLG4
• SHANK3