Seroatlas · Human Serome Atlas

ADGRA2

Adhesion G protein-coupled receptor A2

Also known as: AGRA2_HUMAN, DKFZp434C211, DKFZp434J0911, FLJ14390, GPR124, KIAA1531, TEM5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96PE1
Gene
ADGRA2
Ensembl
ENSG00000020181
Chromosome
8
Canonical length
1338 aa
Protein class
G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Vesicles,Plasma membrane

OverviewNCBI Gene

Predicted to enable G protein-coupled receptor activity. Involved in canonical Wnt signaling pathway. Located in intracellular membrane-bounded organelle and plasma membrane. Part of Wnt signalosome. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

1338 residues, UniProt reviewed canonical sequence.

>Q96PE1|ADGRA2
     1  MGAGGRRMRG APARLLLPLL PWLLLLLAPE ARGAPGCPLS IRSCKCSGER PKGLSGGVPG
    61  PARRRVVCSG GDLPEPPEPG LLPNGTVTLL LSNNKITGLR NGSFLGLSLL EKLDLRNNII
   121  STVQPGAFLG LGELKRLDLS NNRIGCLTSE TFQGLPRLLR LNISGNIFSS LQPGVFDELP
   181  ALKVVDLGTE FLTCDCHLRW LLPWAQNRSL QLSEHTLCAY PSALHAQALG SLQEAQLCCE
   241  GALELHTHHL IPSLRQVVFQ GDRLPFQCSA SYLGNDTRIR WYHNRAPVEG DEQAGILLAE
   301  SLIHDCTFIT SELTLSHIGV WASGEWECTV SMAQGNASKK VEIVVLETSA SYCPAERVAN
   361  NRGDFRWPRT LAGITAYQSC LQYPFTSVPL GGGAPGTRAS RRCDRAGRWE PGDYSHCLYT
   421  NDITRVLYTF VLMPINASNA LTLAHQLRVY TAEAASFSDM MDVVYVAQMI QKFLGYVDQI
   481  KELVEVMVDM ASNLMLVDEH LLWLAQREDK ACSRIVGALE RIGGAALSPH AQHISVNARN
   541  VALEAYLIKP HSYVGLTCTA FQRREGGVPG TRPGSPGQNP PPEPEPPADQ QLRFRCTTGR
   601  PNVSLSSFHI KNSVALASIQ LPPSLFSSLP AALAPPVPPD CTLQLLVFRN GRLFHSHSNT
   661  SRPGAAGPGK RRGVATPVIF AGTSGCGVGN LTEPVAVSLR HWAEGAEPVA AWWSQEGPGE
   721  AGGWTSEGCQ LRSSQPNVSA LHCQHLGNVA VLMELSAFPR EVGGAGAGLH PVVYPCTALL
   781  LLCLFATIIT YILNHSSIRV SRKGWHMLLN LCFHIAMTSA VFAGGITLTN YQMVCQAVGI
   841  TLHYSSLSTL LWMGVKARVL HKELTWRAPP PQEGDPALPT PSPMLRFYLI AGGIPLIICG
   901  ITAAVNIHNY RDHSPYCWLV WRPSLGAFYI PVALILLITW IYFLCAGLRL RGPLAQNPKA
   961  GNSRASLEAG EELRGSTRLR GSGPLLSDSG SLLATGSARV GTPGPPEDGD SLYSPGVQLG
  1021  ALVTTHFLYL AMWACGALAV SQRWLPRVVC SCLYGVAASA LGLFVFTHHC ARRRDVRASW
  1081  RACCPPASPA APHAPPRALP AAAEDGSPVF GEGPPSLKSS PSGSSGHPLA LGPCKLTNLQ
  1141  LAQSQVCEAG AAAGGEGEPE PAGTRGNLAH RHPNNVHHGR RAHKSRAKGH RAGEACGKNR
  1201  LKALRGGAAG ALELLSSESG SLHNSPTDSY LGSSRNSPGA GLQLEGEPML TPSEGSDTSA
  1261  APLSEAGRAG QRRSASRDSL KGGGALEKES HRRSYPLNAA SLNGAPKGGK YDDVTLMGAE
  1321  VASGGCMKTG LWKSETTV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADGRA2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
52 nTPM

Expression across tissuesHPA

Tissue

  • seminal vesicle: 52 nTPM
  • cervix: 50 nTPM
  • placenta: 46 nTPM
  • endometrium: 39 nTPM
  • fallopian tube: 38 nTPM
  • prostate: 37 nTPM

Single-cell type

  • leydig cells: 84 nCPM
  • endometrial luminal cells: 83 nCPM
  • pericytes: 75 nCPM
  • müller glia: 73 nCPM
  • vascular smooth muscle cells: 70 nCPM
  • endometrial stromal cells: 64 nCPM

Immune cell

  • classical monocyte: 0.1 nTPM
  • basophil: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • thalamus: 21 nTPM
  • amygdala: 18 nTPM
  • cerebral cortex: 17 nTPM
  • hippocampal formation: 17 nTPM
  • cerebellum: 15 nTPM
  • basal ganglia: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.61
gnomAD pLI
0
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ADGRA2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADGRA2 as an antibody target. Whether an autoantibody or antibody against ADGRA2 could matter depends on whether native ADGRA2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADGRA2 is annotated at the cell surface, where native ADGRA2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ADGRA2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ADGRA2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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