Seroatlas · Human Serome Atlas

GLP1R

Glucagon-like peptide 1 receptor

Also known as: GLP-1R, GLP1R_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P43220
Gene
GLP1R
Ensembl
ENSG00000112164
Chromosome
6
Canonical length
463 aa
Protein class
FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins, Transporters
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]

Canonical amino-acid sequenceUniProt

463 residues, UniProt reviewed canonical sequence.

>P43220|GLP1R
     1  MAGAPGPLRL ALLLLGMVGR AGPRPQGATV SLWETVQKWR EYRRQCQRSL TEDPPPATDL
    61  FCNRTFDEYA CWPDGEPGSF VNVSCPWYLP WASSVPQGHV YRFCTAEGLW LQKDNSSLPW
   121  RDLSECEESK RGERSSPEEQ LLFLYIIYTV GYALSFSALV IASAILLGFR HLHCTRNYIH
   181  LNLFASFILR ALSVFIKDAA LKWMYSTAAQ QHQWDGLLSY QDSLSCRLVF LLMQYCVAAN
   241  YYWLLVEGVY LYTLLAFSVL SEQWIFRLYV SIGWGVPLLF VVPWGIVKYL YEDEGCWTRN
   301  SNMNYWLIIR LPILFAIGVN FLIFVRVICI VVSKLKANLM CKTDIKCRLA KSTLTLIPLL
   361  GTHEVIFAFV MDEHARGTLR FIKLFTELSF TSFQGLMVAI LYCFVNNEVQ LEFRKSWERW
   421  RLEHLHIQRD SSMKPLKCPT SSLSSGATAG SSMYTATCQA SCS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GLP1R can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
8.6 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 8.6 nTPM
  • heart muscle: 2.6 nTPM
  • salivary gland: 2.1 nTPM
  • hypothalamus: 1.5 nTPM
  • basal ganglia: 1.3 nTPM
  • cerebral cortex: 1.2 nTPM

Single-cell type

  • tuft cells: 46 nCPM
  • pancreatic islet cells: 23 nCPM
  • lacrimal acinar cells: 19 nCPM
  • pancreatic acinar cells: 16 nCPM
  • other brain neurons: 11 nCPM
  • neuroendocrine cells: 8 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hypothalamus: 8.2 nTPM
  • pons: 3.2 nTPM
  • medulla oblongata: 2.9 nTPM
  • spinal cord: 2.8 nTPM
  • basal ganglia: 2.3 nTPM
  • hippocampal formation: 1.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.44
gnomAD pLI
0.29
gnomAD missense Z
1.68
DepMap mean gene effect
0.09
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GLP1R as an antibody target. Whether an autoantibody or antibody against GLP1R could matter depends on whether native GLP1R is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GLP1R is annotated at the cell surface, where native GLP1R is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GLP1R as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GLP1R. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...