Seroatlas · Human Serome Atlas

GLP2R

Glucagon-like peptide 2 receptor

Also known as: GLP2R_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95838
Gene
GLP2R
Ensembl
ENSG00000065325
Chromosome
17
Canonical length
553 aa
Protein class
FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins
Subcellular location
Plasma membrane

OverviewNCBI Gene

This gene encodes a G protein-coupled receptor that is closely related to the glucagon receptor and binds to glucagon-like peptide-2 (GLP2). Signalling through GLP2 stimulates intestinal growth and increases villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. [provided by RefSeq, Dec 2014]

Canonical amino-acid sequenceUniProt

553 residues, UniProt reviewed canonical sequence.

>O95838|GLP2R
     1  MKLGSSRAGP GRGSAGLLPG VHELPMGIPA PWGTSPLSFH RKCSLWAPGR PFLTLVLLVS
    61  IKQVTGSLLE ETTRKWAQYK QACLRDLLKE PSGIFCNGTF DQYVCWPHSS PGNVSVPCPS
   121  YLPWWSEESS GRAYRHCLAQ GTWQTIENAT DIWQDDSECS ENHSFKQNVD RYALLSTLQL
   181  MYTVGYSFSL ISLFLALTLL LFLRKLHCTR NYIHMNLFAS FILRTLAVLV KDVVFYNSYS
   241  KRPDNENGWM SYLSEMSTSC RSVQVLLHYF VGANYLWLLV EGLYLHTLLE PTVLPERRLW
   301  PRYLLLGWAF PVLFVVPWGF ARAHLENTGC WTTNGNKKIW WIIRGPMMLC VTVNFFIFLK
   361  ILKLLISKLK AHQMCFRDYK YRLAKSTLVL IPLLGVHEIL FSFITDDQVE GFAKLIRLFI
   421  QLTLSSFHGF LVALQYGFAN GEVKAELRKY WVRFLLARHS GCRACVLGKD FRFLGKCPKK
   481  LSEGDGAEKL RKLQPSLNSG RLLHLAMRGL GELGAQPQQD HARWPRGSSL SECSEGDVTM
   541  ANTMEEILEE SEI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GLP2R can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • colon: 13 nTPM
  • urinary bladder: 12 nTPM
  • gallbladder: 11 nTPM
  • duodenum: 9.3 nTPM
  • small intestine: 8.4 nTPM
  • adipose tissue: 8.2 nTPM

Single-cell type

  • rod photoreceptor cells: 59 nCPM
  • cone photoreceptor cells: 21 nCPM
  • fibro-adipogenic progenitors: 13 nCPM
  • hepatic stellate cells: 13 nCPM
  • leydig cells: 8.8 nCPM
  • fibroblasts: 7.6 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 9.3 nTPM
  • basal ganglia: 7.8 nTPM
  • white matter: 5.6 nTPM
  • hippocampal formation: 2.6 nTPM
  • midbrain: 2.1 nTPM
  • amygdala: 1.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.93
gnomAD pLI
0
gnomAD missense Z
1.16
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GLP2R as an antibody target. Whether an autoantibody or antibody against GLP2R could matter depends on whether native GLP2R is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GLP2R is annotated at the cell surface, where native GLP2R is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GLP2R as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GLP2R. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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