ADGRB3

Protein identityUniProt · HPA

UniProt accession

O60242

Gene

ADGRB3

Ensembl

ENSG00000135298

Chromosome

6

Canonical length

1522 aa

Protein class

G-protein coupled receptors, Plasma proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

This p53-target gene encodes a brain-specific angiogenesis inhibitor, a seven-span transmembrane protein, and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities, and may also play a role in angiogenesis. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1522 residues, UniProt reviewed canonical sequence.

>O60242|ADGRB3
     1  MKAVRNLLIY IFSTYLLVMF GFNAAQDFWC STLVKGVIYG SYSVSEMFPK NFTNCTWTLE
    61  NPDPTKYSIY LKFSKKDLSC SNFSLLAYQF DHFSHEKIKD LLRKNHSIMQ LCNSKNAFVF
   121  LQYDKNFIQI RRVFPTNFPG LQKKGEEDQK SFFEFLVLNK VSPSQFGCHV LCTWLESCLK
   181  SENGRTESCG IMYTKCTCPQ HLGEWGIDDQ SLILLNNVVL PLNEQTEGCL TQELQTTQVC
   241  NLTREAKRPP KEEFGMMGDH TIKSQRPRSV HEKRVPQEQA DAAKFMAQTG ESGVEEWSQW
   301  STCSVTCGQG SQVRTRTCVS PYGTHCSGPL RESRVCNNTA LCPVHGVWEE WSPWSLCSFT
   361  CGRGQRTRTR SCTPPQYGGR PCEGPETHHK PCNIALCPVD GQWQEWSSWS QCSVTCSNGT
   421  QQRSRQCTAA AHGGSECRGP WAESRECYNP ECTANGQWNQ WGHWSGCSKS CDGGWERRIR
   481  TCQGAVITGQ QCEGTGEEVR RCNEQRCPAP YEICPEDYLM SMVWKRTPAG DLAFNQCPLN
   541  ATGTTSRRCS LSLHGVAFWE QPSFARCISN EYRHLQHSIK EHLAKGQRML AGDGMSQVTK
   601  TLLDLTQRKN FYAGDLLMSV EILRNVTDTF KRASYIPASD GVQNFFQIVS NLLDEENKEK
   661  WEDAQQIYPG SIELMQVIED FIHIVGMGMM DFQNSYLMTG NVVASIQKLP AASVLTDINF
   721  PMKGRKGMVD WARNSEDRVV IPKSIFTPVS SKELDESSVF VLGAVLYKNL DLILPTLRNY
   781  TVINSKIIVV TIRPEPKTTD SFLEIELAHL ANGTLNPYCV LWDDSKTNES LGTWSTQGCK
   841  TVLTDASHTK CLCDRLSTFA ILAQQPREII MESSGTPSVT LIVGSGLSCL ALITLAVVYA
   901  ALWRYIRSER SIILINFCLS IISSNILILV GQTQTHNKSI CTTTTAFLHF FFLASFCWVL
   961  TEAWQSYMAV TGKIRTRLIR KRFLCLGWGL PALVVATSVG FTRTKGYGTD HYCWLSLEGG
  1021  LLYAFVGPAA AVVLVNMVIG ILVFNKLVSR DGILDKKLKH RAGQMSEPHS GLTLKCAKCG
  1081  VVSTTALSAT TASNAMASLW SSCVVLPLLA LTWMSAVLAM TDKRSILFQI LFAVFDSLQG
  1141  FVIVMVHCIL RREVQDAFRC RLRNCQDPIN ADSSSSFPNG HAQIMTDFEK DVDIACRSVL
  1201  HKDIGPCRAA TITGTLSRIS LNDDEEEKGT NPEGLSYSTL PGNVISKVII QQPTGLHMPM
  1261  SMNELSNPCL KKENSELRRT VYLCTDDNLR GADMDIVHPQ ERMMESDYIV MPRSSVNNQP
  1321  SMKEESKMNI GMETLPHERL LHYKVNPEFN MNPPVMDQFN MNLEQHLAPQ EHMQNLPFEP
  1381  RTAVKNFMAS ELDDNAGLSR SETGSTISMS SLERRKSRYS DLDFEKVMHT RKRHMELFQE
  1441  LNQKFQTLDR FRDIPNTSSM ENPAPNKNPW DTFKNPSEYP HYTTINVLDT EAKDALELRP
  1501  AEWEKCLNLP LDVQEGDFQT EV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADGRB3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

7

Mean surface accessibility (rSASA)

0.43

Highest tissue expression

28 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ADGRB3.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 182 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Short stature

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.14

gnomAD pLI

1

DepMap mean gene effect

-0.05

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell surface receptor signaling pathway
• G protein-coupled receptor signaling pathway
• maintenance of synapse structure
• motor learning
• myoblast fusion
• negative regulation of angiogenesis
• neuron remodeling
• positive regulation of synapse assembly
• regulation of dendrite morphogenesis
• regulation of synapse maturation
• regulation of synapse pruning

Molecular functions

• G protein-coupled receptor activity
• GTPase activator activity

Cellular components

• cerebellar climbing fiber to Purkinje cell synapse
• membrane
• plasma membrane
• postsynapse
• postsynaptic density membrane
• synaptic cleft

Protein domainsUniProt · Pfam · InterPro

• GPS motif
• GPCR, family 2, secretin-like
• CUB domain
• Thrombospondin type-1 (TSP1) repeat
• GPCR, family 2, extracellular hormone receptor domain
• GPCR, family 2, brain-specific angiogenesis inhibitor
• GPCR, family 2-like, 7TM
• GPCR, family 2, secretin-like, conserved site
• AGRL2-4 , GAIN subdomain A
• Thrombospondin type-1 repeat superfamily
• GPCR family 2, extracellular hormone receptor domain superfamily
• Adhesion G protein-coupled receptor B, N-terminal domain
• GAIN domain superfamily
• GAIN, subdomain B
• 7 transmembrane receptor (Secretin family)
• Thrombospondin type 1 domain
• GPCR proteolysis site, GPS, motif
• Hormone receptor domain
• AGRL2-4 GAIN subdomain A
• Adhesion GPCR B N-terminal region

KeywordsUniProt

• Cell membrane
• Disulfide bond
• G-protein coupled receptor
• Glycoprotein
• Membrane
• Phosphoprotein
• Receptor
• Repeat
• Signal
• Transducer
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of ADGRB3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ELMO1
• ELMO2
• ELMO3
• C1QL3
• C1QL4
• C1QL2
• C1QL1