CALCR
Calcitonin receptor
Also known as: CALCR_HUMAN
Protein identityUniProt · HPA
- UniProt accession
- P30988
- Gene
- CALCR
- Canonical length
- 474 aa
- Protein class
- Human disease related genes, Predicted membrane proteins
OverviewNCBI Gene
No narrative summary is available for CALCR in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
474 residues, UniProt reviewed canonical sequence.
>P30988|CALCR
1 MRFTFTSRCL ALFLLLNHPT PILPAFSNQT YPTIEPKPFL YVVGRKKMMD AQYKCYDRMQ
61 QLPAYQGEGP YCNRTWDGWL CWDDTPAGVL SYQFCPDYFP DFDPSEKVTK YCDEKGVWFK
121 HPENNRTWSN YTMCNAFTPE KLKNAYVLYY LAIVGHSLSI FTLVISLGIF VFFRSLGCQR
181 VTLHKNMFLT YILNSMIIII HLVEVVPNGE LVRRDPVSCK ILHFFHQYMM ACNYFWMLCE
241 GIYLHTLIVV AVFTEKQRLR WYYLLGWGFP LVPTTIHAIT RAVYFNDNCW LSVETHLLYI
301 IHGPVMAALV VNFFFLLNIV RVLVTKMRET HEAESHMYLK AVKATMILVP LLGIQFVVFP
361 WRPSNKMLGK IYDYVMHSLI HFQGFFVATI YCFCNNEVQT TVKRQWAQFK IQWNQRWGRR
421 PSNRSARAAA AAAEAGDIPI YICHQELRNE PANNQGEESA EIIPLNIIEQ ESSALocalizationUniProt · AlphaFold · HPA
Whether an antibody against CALCR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 7
- Mean surface accessibility (rSASA)
- 0.36
- Highest tissue expression
- 4 nTPM
Expression across tissuesHPA
Tissue
- hypothalamus: 4 nTPM
- kidney: 1.4 nTPM
- skeletal muscle: 1 nTPM
- tongue: 0.7 nTPM
- testis: 0.6 nTPM
- basal ganglia: 0.5 nTPM
Single-cell type
- myosatellite cells: 661 nCPM
- distal convoluted tubule cells: 396 nCPM
- renal collecting duct intercalated cells: 184 nCPM
- loop of henle epithelial cells: 131 nCPM
- neuroendocrine cells: 40 nCPM
- other brain neurons: 36 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- hypothalamus: 12 nTPM
- pons: 7.6 nTPM
- medulla oblongata: 4.3 nTPM
- midbrain: 3.6 nTPM
- basal ganglia: 3.4 nTPM
- thalamus: 3.3 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.93
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.52
- DepMap mean gene effect
- 0
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- adenylate cyclase-activating G protein-coupled receptor signaling pathway
- amylin receptor 1 signaling pathway
- amylin receptor 2 signaling pathway
- amylin receptor 3 signaling pathway
- amylin receptor signaling pathway
- calcitonin family receptor signaling pathway
- calcitonin gene-related peptide receptor signaling pathway
- cell surface receptor signaling pathway
- negative regulation of ossification
- ossification
- osteoclast differentiation
- positive regulation of calcium-mediated signaling
- positive regulation of cAMP/PKA signal transduction
- positive regulation of cytosolic calcium ion concentration
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of gene expression
- positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
- regulation of mRNA stability
- response to amyloid-beta
- response to glucocorticoid
Molecular functions
- amylin receptor activity
- amyloid-beta binding
- calcitonin gene-related peptide receptor activity
- calcitonin receptor activity
- calcitonin binding
- calcitonin family receptor activity
Cellular components
- acrosomal vesicle
- amylin receptor complex 3
- axon
- cilium
- plasma membrane
- amylin receptor complex 1
- amylin receptor complex 2
Protein domainsUniProt · Pfam · InterPro
- GPCR, family 2, secretin-like
- GPCR, family 2, extracellular hormone receptor domain
- GPCR, family 2, calcitonin receptor family
- GPCR, family 2-like, 7TM
- GPCR, family 2, secretin-like, conserved site
- GPCR family 2, extracellular hormone receptor domain superfamily
- G-protein coupled receptor 2
- 7 transmembrane receptor (Secretin family)
- Hormone receptor domain
- GPCR, family 2, calcitonin receptor
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of CALCR in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CALCR as an antibody target. Whether an autoantibody or antibody against CALCR could matter depends on whether native CALCR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CALCR is annotated at the cell surface, where native CALCR is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label CALCR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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