ADGRG2

Protein identityUniProt · HPA

UniProt accession

Q8IZP9

Gene

ADGRG2

Ensembl

ENSG00000173698

Chromosome

X

Canonical length

1017 aa

Protein class

Disease related genes, G-protein coupled receptors, Human disease related genes, Plasma proteins, Potential drug targets, Predicted membrane proteins, Transporters

Subcellular location

Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes a member of the G protein-coupled receptor family described as an epididymis-specific transmembrane protein. The encoded protein may be proteolytically processed as it contains a motif shown to be a protein scission motif in some members of this family (PMID: 11973329). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

1017 residues, UniProt reviewed canonical sequence.

>Q8IZP9|ADGRG2
     1  MVFSVRQCGH VGRTEEVLLT FKIFLVIICL HVVLVTSLEE DTDNSSLSPP PAKLSVVSFA
    61  PSSNGTPEVE TTSLNDVTLS LLPSNETEKT KITIVKTFNA SGVKPQRNIC NLSSICNDSA
   121  FFRGEIMFQY DKESTVPQNQ HITNGTLTGV LSLSELKRSE LNKTLQTLSE TYFIMCATAE
   181  AQSTLNCTFT IKLNNTMNAC AVIAALERVK IRPMEHCCCS VRIPCPSSPE ELEKLQCDLQ
   241  DPIVCLADHP RGPPFSSSQS IPVVPRATVL SQVPKATSFA EPPDYSPVTH NVPSPIGEIQ
   301  PLSPQPSAPI ASSPAIDMPP QSETISSPMP QTHVSGTPPP VKASFSSPTV SAPANVNTTS
   361  APPVQTDIVN TSSISDLENQ VLQMEKALSL GSLEPNLAGE MINQVSRLLH SPPDMLAPLA
   421  QRLLKVVDDI GLQLNFSNTT ISLTSPSLAL AVIRVNASSF NTTTFVAQDP ANLQVSLETQ
   481  APENSIGTIT LPSSLMNNLP AHDMELASRV QFNFFETPAL FQDPSLENLS LISYVISSSV
   541  ANLTVRNLTR NVTVTLKHIN PSQDELTVRC VFWDLGRNGG RGGWSDNGCS VKDRRLNETI
   601  CTCSHLTSFG VLLDLSRTSV LPAQMMALTF ITYIGCGLSS IFLSVTLVTY IAFEKIRRDY
   661  PSKILIQLCA ALLLLNLVFL LDSWIALYKM QGLCISVAVF LHYFLLVSFT WMGLEAFHMY
   721  LALVKVFNTY IRKYILKFCI VGWGVPAVVV TIILTISPDN YGLGSYGKFP NGSPDDFCWI
   781  NNNAVFYITV VGYFCVIFLL NVSMFIVVLV QLCRIKKKKQ LGAQRKTSIQ DLRSIAGLTF
   841  LLGITWGFAF FAWGPVNVTF MYLFAIFNTL QGFFIFIFYC VAKENVRKQW RRYLCCGKLR
   901  LAENSDWSKT ATNGLKKQTV NQGVSSSSNS LQSSSNSTNS TTLLVNNDCS VHASGNGNAS
   961  TERNGVSFSV QNGDVCLHDF TGKQHMFNEK EDSCNGKGRM ALRRTSKRGS LHFIEQM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADGRG2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

7

Mean surface accessibility (rSASA)

0.44

Highest tissue expression

1,159 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ADGRG2.

Disease | AllUniProt

Conditions ADGRG2 is implicated in, by any mechanism.

• Congenital bilateral aplasia of the vas deferens, X-linked (CBAVDX) MIM:300985

Disease | GeneticClinVar

11 pathogenic / likely-pathogenic of 346 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Congenital bilateral aplasia of vas deferens from CFTR mutation
• Vas deferens, congenital bilateral aplasia of, X-linked
• Obstructive azoospermia

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.34

gnomAD pLI

0.93

DepMap mean gene effect

0.12

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• adenylate cyclase-activating G protein-coupled receptor signaling pathway
• cell surface receptor signaling pathway
• G protein-coupled receptor signaling pathway
• phospholipase C-activating G protein-coupled receptor signaling pathway
• spermatid development
• spermatogenesis

Molecular functions

• G protein-coupled receptor activity

Cellular components

• apical plasma membrane
• cell surface
• cytosol
• extracellular exosome
• membrane
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• GPS motif
• GPCR, family 2, secretin-like
• GPCR, family 2-like, 7TM
• GPCR, family 2, secretin-like, conserved site
• GAIN domain superfamily
• GAIN, subdomain B
• Adhesion G-protein coupled receptor G2/6, GAIN domain
• 7 transmembrane receptor (Secretin family)
• GPCR proteolysis site, GPS, motif
• ADGRG2-like, GAIN domain
• ADGRG2, N-terminal domain
• ADGRG2, N-terminal domain

KeywordsUniProt

• Cell membrane
• Disulfide bond
• G-protein coupled receptor
• Glycoprotein
• Membrane
• Phosphoprotein
• Receptor
• Signal
• Transducer
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of ADGRG2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CFTR