PTH2R

Protein identityUniProt · HPA

UniProt accession

P49190

Gene

PTH2R

Ensembl

ENSG00000144407

Chromosome

2

Canonical length

550 aa

Protein class

FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene is a member of the G-protein coupled receptor 2 family. This protein is a receptor for parathyroid hormone (PTH). This receptor is more selective in ligand recognition and has a more specific tissue distribution compared to parathyroid hormone receptor 1 (PTHR1). It is activated only by PTH and not by parathyroid hormone-like hormone (PTHLH) and is particularly abundant in brain and pancreas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

Canonical amino-acid sequenceUniProt

550 residues, UniProt reviewed canonical sequence.

>P49190|PTH2R
     1  MAGLGASLHV WGWLMLGSCL LARAQLDSDG TITIEEQIVL VLKAKVQCEL NITAQLQEGE
    61  GNCFPEWDGL ICWPRGTVGK ISAVPCPPYI YDFNHKGVAF RHCNPNGTWD FMHSLNKTWA
   121  NYSDCLRFLQ PDISIGKQEF FERLYVMYTV GYSISFGSLA VAILIIGYFR RLHCTRNYIH
   181  MHLFVSFMLR ATSIFVKDRV VHAHIGVKEL ESLIMQDDPQ NSIEATSVDK SQYIGCKIAV
   241  VMFIYFLATN YYWILVEGLY LHNLIFVAFF SDTKYLWGFI LIGWGFPAAF VAAWAVARAT
   301  LADARCWELS AGDIKWIYQA PILAAIGLNF ILFLNTVRVL ATKIWETNAV GHDTRKQYRK
   361  LAKSTLVLVL VFGVHYIVFV CLPHSFTGLG WEIRMHCELF FNSFQGFFVS IIYCYCNGEV
   421  QAEVKKMWSR WNLSVDWKRT PPCGSRRCGS VLTTVTHSTS SQSQVAASTR MVLISGKAAK
   481  IASRQPDSHI TLPGYVWSNS EQDCLPHSFH EETKEDSGRQ GDDILMEKPS RPMESNPDTE
   541  GCQGETEDVL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PTH2R can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

7

Mean surface accessibility (rSASA)

0.41

Highest tissue expression

15 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PTH2R.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 129 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Syndromic intellectual disability

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.39

gnomAD pLI

0

gnomAD missense Z

-0.77

DepMap mean gene effect

-0.01

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• adenylate cyclase-modulating G protein-coupled receptor signaling pathway
• cell surface receptor signaling pathway
• G protein-coupled receptor signaling pathway
• positive regulation of cold-induced thermogenesis

Molecular functions

• G protein-coupled peptide receptor activity
• parathyroid hormone receptor activity
• peptide hormone binding

Cellular components

• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• GPCR, family 2, secretin-like
• GPCR, family 2, extracellular hormone receptor domain
• GPCR, family 2-like, 7TM
• GPCR, family 2, secretin-like, conserved site
• GPCR family 2, extracellular hormone receptor domain superfamily
• G-protein coupled receptor 2
• 7 transmembrane receptor (Secretin family)
• Hormone receptor domain

KeywordsUniProt

• Cell membrane
• G-protein coupled receptor
• Glycoprotein
• Membrane
• Receptor
• Signal
• Transducer
• Transmembrane
• Transmembrane helix