Seroatlas · Human Serome Atlas

ADGRL1

Adhesion G protein-coupled receptor L1

Also known as: AGRL1_HUMAN, CIRL1, KIAA0821, LEC2, LPHN1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O94910
Gene: ADGRL1
Ensembl: ENSG00000072071
Chromosome: 19
Canonical length: 1474 aa
Protein class: G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]

Canonical amino-acid sequenceUniProt

1474 residues, UniProt reviewed canonical sequence.

>O94910|ADGRL1
     1  MARLAAVLWN LCVTAVLVTS ATQGLSRAGL PFGLMRRELA CEGYPIELRC PGSDVIMVEN
    61  ANYGRTDDKI CDADPFQMEN VQCYLPDAFK IMSQRCNNRT QCVVVAGSDA FPDPCPGTYK
   121  YLEVQYDCVP YKVEQKVFVC PGTLQKVLEP TSTHESEHQS GAWCKDPLQA GDRIYVMPWI
   181  PYRTDTLTEY ASWEDYVAAR HTTTYRLPNR VDGTGFVVYD GAVFYNKERT RNIVKYDLRT
   241  RIKSGETVIN TANYHDTSPY RWGGKTDIDL AVDENGLWVI YATEGNNGRL VVSQLNPYTL
   301  RFEGTWETGY DKRSASNAFM VCGVLYVLRS VYVDDDSEAA GNRVDYAFNT NANREEPVSL
   361  TFPNPYQFIS SVDYNPRDNQ LYVWNNYFVV RYSLEFGPPD PSAGPATSPP LSTTTTARPT
   421  PLTSTASPAA TTPLRRAPLT THPVGAINQL GPDLPPATAP VPSTRRPPAP NLHVSPELFC
   481  EPREVRRVQW PATQQGMLVE RPCPKGTRGI ASFQCLPALG LWNPRGPDLS NCTSPWVNQV
   541  AQKIKSGENA ANIASELARH TRGSIYAGDV SSSVKLMEQL LDILDAQLQA LRPIERESAG
   601  KNYNKMHKRE RTCKDYIKAV VETVDNLLRP EALESWKDMN ATEQVHTATM LLDVLEEGAF
   661  LLADNVREPA RFLAAKENVV LEVTVLNTEG QVQELVFPQE EYPRKNSIQL SAKTIKQNSR
   721  NGVVKVVFIL YNNLGLFLST ENATVKLAGE AGPGGPGGAS LVVNSQVIAA SINKESSRVF
   781  LMDPVIFTVA HLEDKNHFNA NCSFWNYSER SMLGYWSTQG CRLVESNKTH TTCACSHLTN
   841  FAVLMAHREI YQGRINELLL SVITWVGIVI SLVCLAICIS TFCFLRGLQT DRNTIHKNLC
   901  INLFLAELLF LVGIDKTQYE IACPIFAGLL HYFFLAAFSW LCLEGVHLYL LLVEVFESEY
   961  SRTKYYYLGG YCFPALVVGI AAAIDYRSYG TEKACWLRVD NYFIWSFIGP VSFVIVVNLV
  1021  FLMVTLHKMI RSSSVLKPDS SRLDNIKSWA LGAIALLFLL GLTWAFGLLF INKESVVMAY
  1081  LFTTFNAFQG VFIFVFHCAL QKKVHKEYSK CLRHSYCCIR SPPGGTHGSL KTSAMRSNTR
  1141  YYTGTQSRIR RMWNDTVRKQ TESSFMAGDI NSTPTLNRGT MGNHLLTNPV LQPRGGTSPY
  1201  NTLIAESVGF NPSSPPVFNS PGSYREPKHP LGGREACGMD TLPLNGNFNN SYSLRSGDFP
  1261  PGDGGPEPPR GRNLADAAAF EKMIISELVH NNLRGSSSAA KGPPPPEPPV PPVPGGGGEE
  1321  EAGGPGGADR AEIELLYKAL EEPLLLPRAQ SVLYQSDLDE SESCTAEDGA TSRPLSSPPG
  1381  RDSLYASGAN LRDSPSYPDS SPEGPSEALP PPPPAPPGPP EIYYTSRPPA LVARNPLQGY
  1441  YQVRRPSHEG YLAAPGLEGP GPDGDGQMQL VTSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADGRL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 70 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 70 nTPM
cerebral cortex: 53 nTPM
hippocampal formation: 42 nTPM
amygdala: 38 nTPM
basal ganglia: 36 nTPM
hypothalamus: 27 nTPM

Single-cell type

brain excitatory neurons: 83 nCPM
brain inhibitory neurons: 82 nCPM
oligodendrocyte progenitor cells: 67 nCPM
other brain neurons: 55 nCPM
bergmann glia: 47 nCPM
astrocytes: 42 nCPM

Immune cell

gdT-cell: 0.3 nTPM
NK-cell: 0.2 nTPM
plasmacytoid DC: 0.2 nTPM
MAIT T-cell: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM
myeloid DC: 0.1 nTPM

Brain region

cerebral cortex: 114 nTPM
hippocampal formation: 74 nTPM
white matter: 69 nTPM
amygdala: 63 nTPM
basal ganglia: 60 nTPM
thalamus: 52 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ADGRL1.

Disease | AllUniProt

Conditions ADGRL1 is implicated in, by any mechanism.

Developmental delay, behavioral abnormalities, and neuropsychiatric disorders (DEDBANP) MIM:620065

Disease | GeneticClinVar

31 pathogenic / likely-pathogenic of 366 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Developmental delay, behavioral abnormalities, and neuropsychiatric disorders
Global developmental delay
Attention deficit hyperactivity disorder
Intellectual disability
Autistic behavior

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.19
gnomAD pLI: 1
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ADGRL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CACNA1A

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADGRL1 as an antibody target. Whether an autoantibody or antibody against ADGRL1 could matter depends on whether native ADGRL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADGRL1 is annotated at the cell surface, where native ADGRL1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ADGRL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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