Seroatlas · Human Serome Atlas

ADGRB2

Adhesion G protein-coupled receptor B2

Also known as: AGRB2_HUMAN, BAI2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O60241
Gene: ADGRB2
Ensembl: ENSG00000121753
Chromosome: 1
Canonical length: 1585 aa
Protein class: G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, Transporters
Subcellular location: Plasma membrane
Secretome location: Intracellular and membrane

OverviewNCBI Gene

This gene encodes a a seven-span transmembrane protein that is thought to be a member of the secretin receptor family. The encoded protein is a brain-specific inhibitor of angiogenesis. The mature peptide may be further cleaved into additional products (PMID:20367554). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

Canonical amino-acid sequenceUniProt

1585 residues, UniProt reviewed canonical sequence.

>O60241|ADGRB2
     1  MENTGWMGKG HRMTPACPLL LSVILSLRLA TAFDPAPSAC SALASGVLYG AFSLQDLFPT
    61  IASGCSWTLE NPDPTKYSLY LRFNRQEQVC AHFAPRLLPL DHYLVNFTCL RPSPEEAVAQ
   121  AESEVGRPEE EEAEAAAGLE LCSGSGPFTF LHFDKNFVQL CLSAEPSEAP RLLAPAALAF
   181  RFVEVLLINN NNSSQFTCGV LCRWSEECGR AAGRACGFAQ PGCSCPGEAG AGSTTTTSPG
   241  PPAAHTLSNA LVPGGPAPPA EADLHSGSSN DLFTTEMRYG EEPEEEPKVK TQWPRSADEP
   301  GLYMAQTGDP AAEEWSPWSV CSLTCGQGLQ VRTRSCVSSP YGTLCSGPLR ETRPCNNSAT
   361  CPVHGVWEEW GSWSLCSRSC GRGSRSRMRT CVPPQHGGKA CEGPELQTKL CSMAACPVEG
   421  QWLEWGPWGP CSTSCANGTQ QRSRKCSVAG PAWATCTGAL TDTRECSNLE CPATDSKWGP
   481  WNAWSLCSKT CDTGWQRRFR MCQATGTQGY PCEGTGEEVK PCSEKRCPAF HEMCRDEYVM
   541  LMTWKKAAAG EIIYNKCPPN ASGSASRRCL LSAQGVAYWG LPSFARCISH EYRYLYLSLR
   601  EHLAKGQRML AGEGMSQVVR SLQELLARRT YYSGDLLFSV DILRNVTDTF KRATYVPSAD
   661  DVQRFFQVVS FMVDAENKEK WDDAQQVSPG SVHLLRVVED FIHLVGDALK AFQSSLIVTD
   721  NLVISIQREP VSAVSSDITF PMRGRRGMKD WVRHSEDRLF LPKEVLSLSS PGKPATSGAA
   781  GSPGRGRGPG TVPPGPGHSH QRLLPADPDE SSYFVIGAVL YRTLGLILPP PRPPLAVTSR
   841  VMTVTVRPPT QPPAEPLITV ELSYIINGTT DPHCASWDYS RADASSGDWD TENCQTLETQ
   901  AAHTRCQCQH LSTFAVLAQP PKDLTLELAG SPSVPLVIGC AVSCMALLTL LAIYAAFWRF
   961  IKSERSIILL NFCLSILASN ILILVGQSRV LSKGVCTMTA AFLHFFFLSS FCWVLTEAWQ
  1021  SYLAVIGRMR TRLVRKRFLC LGWGLPALVV AVSVGFTRTK GYGTSSYCWL SLEGGLLYAF
  1081  VGPAAVIVLV NMLIGIIVFN KLMARDGISD KSKKQRAGSE RCPWASLLLP CSACGAVPSP
  1141  LLSSASARNA MASLWSSCVV LPLLALTWMS AVLAMTDRRS VLFQALFAVF NSAQGFVITA
  1201  VHCFLRREVQ DVVKCQMGVC RADESEDSPD SCKNGQLQIL SDFEKDVDLA CQTVLFKEVN
  1261  TCNPSTITGT LSRLSLDEDE EPKSCLVGPE GSLSFSPLPG NILVPMAASP GLGEPPPPQE
  1321  ANPVYMCGEG GLRQLDLTWL RPTEPGSEGD YMVLPRRTLS LQPGGGGGGG EDAPRARPEG
  1381  TPRRAAKTVA HTEGYPSFLS VDHSGLGLGP AYGSLQNPYG MTFQPPPPTP SARQVPEPGE
  1441  RSRTMPRTVP GSTMKMGSLE RKKLRYSDLD FEKVMHTRKR HSELYHELNQ KFHTFDRYRS
  1501  QSTAKREKRW SVSSGGAAER SVCTDKPSPG ERPSLSQHRR HQSWSTFKSM TLGSLPPKPR
  1561  ERLTLHRAAA WEPTEPPDGD FQTEV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADGRB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 75 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 75 nTPM
basal ganglia: 53 nTPM
hippocampal formation: 44 nTPM
amygdala: 36 nTPM
cerebellum: 24 nTPM
hypothalamus: 19 nTPM

Single-cell type

brain excitatory neurons: 48 nCPM
brain inhibitory neurons: 40 nCPM
oligodendrocyte progenitor cells: 35 nCPM
late spermatids: 25 nCPM
retinal amacrine cells: 23 nCPM
astrocytes: 22 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hippocampal formation: 227 nTPM
cerebral cortex: 181 nTPM
amygdala: 158 nTPM
basal ganglia: 145 nTPM
white matter: 119 nTPM
hypothalamus: 85 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ADGRB2.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 428 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Progressive spastic paraparesis

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.25
gnomAD pLI: 1
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

G protein-coupled receptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ADGRB2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADGRB2 as an antibody target. Whether an autoantibody or antibody against ADGRB2 could matter depends on whether native ADGRB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADGRB2 is annotated at the cell surface, where native ADGRB2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ADGRB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...