Seroatlas · Human Serome Atlas

GIPR

Gastric inhibitory polypeptide receptor

Also known as: GIPR_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P48546
Gene
GIPR
Ensembl
ENSG00000010310
Chromosome
19
Canonical length
466 aa
Protein class
G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Vesicles
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes. [provided by RefSeq, Oct 2011]

Canonical amino-acid sequenceUniProt

466 residues, UniProt reviewed canonical sequence.

>P48546|GIPR
     1  MTTSPILQLL LRLSLCGLLL QRAETGSKGQ TAGELYQRWE RYRRECQETL AAAEPPSGLA
    61  CNGSFDMYVC WDYAAPNATA RASCPWYLPW HHHVAAGFVL RQCGSDGQWG LWRDHTQCEN
   121  PEKNEAFLDQ RLILERLQVM YTVGYSLSLA TLLLALLILS LFRRLHCTRN YIHINLFTSF
   181  MLRAAAILSR DRLLPRPGPY LGDQALALWN QALAACRTAQ IVTQYCVGAN YTWLLVEGVY
   241  LHSLLVLVGG SEEGHFRYYL LLGWGAPALF VIPWVIVRYL YENTQCWERN EVKAIWWIIR
   301  TPILMTILIN FLIFIRILGI LLSKLRTRQM RCRDYRLRLA RSTLTLVPLL GVHEVVFAPV
   361  TEEQARGALR FAKLGFEIFL SSFQGFLVSV LYCFINKEVQ SEIRRGWHHC RLRRSLGEEQ
   421  RQLPERAFRA LPSGSGPGEV PTSRGLSSGT LPGPGNEASR ELESYC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GIPR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
21 nTPM

Expression across tissuesHPA

Tissue

  • stomach: 21 nTPM
  • heart muscle: 14 nTPM
  • retina: 12 nTPM
  • pancreas: 10 nTPM
  • adipose tissue: 9.3 nTPM
  • breast: 8.8 nTPM

Single-cell type

  • respiratory ciliated cells: 120 nCPM
  • foveolar cells: 95 nCPM
  • neuroendocrine cells: 82 nCPM
  • pancreatic islet cells: 54 nCPM
  • colonocytes: 50 nCPM
  • fallopian tube ciliated cells: 41 nCPM

Immune cell

  • basophil: 1.2 nTPM
  • NK-cell: 1.1 nTPM
  • eosinophil: 0.5 nTPM
  • gdT-cell: 0.5 nTPM
  • neutrophil: 0.5 nTPM
  • naive B-cell: 0.4 nTPM

Brain region

  • midbrain: 12 nTPM
  • pons: 11 nTPM
  • white matter: 11 nTPM
  • thalamus: 11 nTPM
  • cerebral cortex: 8.8 nTPM
  • medulla oblongata: 8.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.76
gnomAD pLI
0
gnomAD missense Z
-0.96
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GIPR as an antibody target. Whether an autoantibody or antibody against GIPR could matter depends on whether native GIPR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GIPR is annotated at the cell surface, where native GIPR is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GIPR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GIPR. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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