Seroatlas · Human Serome Atlas

ADGRG5

Adhesion G-protein coupled receptor G5

Also known as: AGRG5_HUMAN, GPR114, PGR27

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IZF4
Gene: ADGRG5
Ensembl: ENSG00000159618
Chromosome: 16
Canonical length: 528 aa
Protein class: G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Nuclear membrane,Vesicles

OverviewNCBI Gene

This gene encodes a member of the adhesion family of G-protein coupled receptors. Members of this family are characterized by long N-termini and multiple functional domains. They may play a role in the immune system as well as in the central nervous system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

528 residues, UniProt reviewed canonical sequence.

>Q8IZF4|ADGRG5
     1  MDHCGALFLC LCLLTLQNAT TETWEELLSY MENMQVSRGR SSVFSSRQLH QLEQMLLNTS
    61  FPGYNLTLQT PTIQSLAFKL SCDFSGLSLT SATLKRVPQA GGQHARGQHA MQFPAELTRD
   121  ACKTRPRELR LICIYFSNTH FFKDENNSSL LNNYVLGAQL SHGHVNNLRD PVNISFWHNQ
   181  SLEGYTLTCV FWKEGARKQP WGGWSPEGCR TEQPSHSQVL CRCNHLTYFA VLMQLSPALV
   241  PAELLAPLTY ISLVGCSISI VASLITVLLH FHFRKQSDSL TRIHMNLHAS VLLLNIAFLL
   301  SPAFAMSPVP GSACTALAAA LHYALLSCLT WMAIEGFNLY LLLGRVYNIY IRRYVFKLGV
   361  LGWGAPALLV LLSLSVKSSV YGPCTIPVFD SWENGTGFQN MSICWVRSPV VHSVLVMGYG
   421  GLTSLFNLVV LAWALWTLRR LRERADAPSV RACHDTVTVL GLTVLLGTTW ALAFFSFGVF
   481  LLPQLFLFTI LNSLYGFFLF LWFCSQRCRS EAEAKAQIEA FSSSQTTQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADGRG5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 9.9 nTPM

Expression across tissuesHPA

Tissue

tonsil: 9.9 nTPM
lymph node: 9.8 nTPM
spleen: 6.3 nTPM
appendix: 4.7 nTPM
small intestine: 3.7 nTPM
duodenum: 3.5 nTPM

Single-cell type

nk-cells: 138 nCPM
pdcs: 128 nCPM
thymocytes: 71 nCPM
plasma cells: 41 nCPM
microglia: 35 nCPM
t-cells: 31 nCPM

Immune cell

eosinophil: 126 nTPM
plasmacytoid DC: 69 nTPM
gdT-cell: 33 nTPM
NK-cell: 30 nTPM
memory CD8 T-cell: 19 nTPM
MAIT T-cell: 17 nTPM

Brain region

medulla oblongata: 1.6 nTPM
spinal cord: 1.2 nTPM
pons: 1.1 nTPM
midbrain: 0.8 nTPM
thalamus: 0.8 nTPM
hypothalamus: 0.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.51
gnomAD pLI: 0.13
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

G protein-coupled receptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADGRG5 as an antibody target. Whether an autoantibody or antibody against ADGRG5 could matter depends on whether native ADGRG5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADGRG5 is annotated at the cell surface, where native ADGRG5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ADGRG5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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