Seroatlas · Human Serome Atlas

ADGRA1

Adhesion G protein-coupled receptor A1

Also known as: AGRA1_HUMAN, GPR123, KIAA1828

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86SQ6
Gene
ADGRA1
Ensembl
ENSG00000197177
Chromosome
10
Canonical length
560 aa
Protein class
G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a protein that belongs to the adhesion family of G-protein-coupled receptors. Members of this family function in several sensory systems and regulate blood pressure, immune responses, food intake and development. A similar protein in rodents is thought to play a role in in the regulation of neuronal signaling pathways. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Mar 2014]

Canonical amino-acid sequenceUniProt

560 residues, UniProt reviewed canonical sequence.

>Q86SQ6|ADGRA1
     1  MDLKTVLSLP RYPGEFLHPV VYACTAVMLL CLLASFVTYI VHQSAIRISR KGRHTLLNFC
    61  FHAALTFTVF AGGINRTKYP ILCQAVGIVL HYSTLSTMLW IGVTARNIYK QVTKKAPLCL
   121  DTDQPPYPRQ PLLRFYLVSG GVPFIICGVT AATNIRNYGT EDEDTAYCWM AWEPSLGAFY
   181  GPAAIITLVT CVYFLGTYVQ LRRHPGRRYE LRTQPEEQRR LATPEGGRGI RPGTPPAHDA
   241  PGASVLQNEH SFQAQLRAAA FTLFLFTATW AFGALAVSQG HFLDMVFSCL YGAFCVTLGL
   301  FVLIHHCAKR EDVWQCWWAC CPPRKDAHPA LDANGAALGR AACLHSPGLG QPRGFAHPPG
   361  PCKMTNLQAA QGHASCLSPA TPCCAKMHCE PLTADEAHVH LQEEGAFGHD PHLHGCLQGR
   421  TKPPYFSRHP AEEPEYAYHI PSSLDGSPRS SRTDSPPSSL DGPAGTHTLA CCTQGDPFPM
   481  VTQPEGSDGS PALYSCPTQP GREAALGPGH LEMLRRTQSL PFGGPSQNGL PKGKLLEGLP
   541  FGTDGTGNIR TGPWKNETTV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADGRA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 26 nTPM
  • hypothalamus: 18 nTPM
  • hippocampal formation: 15 nTPM
  • amygdala: 13 nTPM
  • midbrain: 9.1 nTPM
  • spinal cord: 6.3 nTPM

Single-cell type

  • oligodendrocyte progenitor cells: 55 nCPM
  • retinal amacrine cells: 39 nCPM
  • adrenal medulla cells: 32 nCPM
  • ependymal cells: 28 nCPM
  • salivary duct cells: 27 nCPM
  • other brain neurons: 20 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • thalamus: 95 nTPM
  • cerebral cortex: 70 nTPM
  • midbrain: 53 nTPM
  • amygdala: 48 nTPM
  • hypothalamus: 46 nTPM
  • white matter: 45 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.71
gnomAD pLI
0.01
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADGRA1 as an antibody target. Whether an autoantibody or antibody against ADGRA1 could matter depends on whether native ADGRA1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADGRA1 is annotated at the cell surface, where native ADGRA1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ADGRA1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ADGRA1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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