SOCS box-like domain superfamily
IPR036036
Definition
The SOCS box was first identified in SH2-domain-containing proteins of the suppressor of cytokines signalling (SOCS) family PMID:9202125 but was later also found in: the WSB (WD-40-repeat-containing proteins with a SOCS box) family, the SSB (SPRY domain-containing proteins with a SOCS box) family, the ASB (ankyrin-repeat-containing proteins with a SOCS box) family, and ras and ras-like GTPases PMID:9419338. The SOCS box found in these proteins is an about 50 amino acid C-terminal domain composed of two blocks of well-conserved residues separated by between 2 and 10 non-conserved residues PMID:9419338. The C-terminal conserved region is an L/P-rich sequence of unknown function, whereas the N-terminal conserved region is a consensus BC box PMID:9869640, which binds to the Elongin BC complex [[cite:PMID:9869640], [cite:PMID:10051596]]. It has been demonstrated that this association couple bound proteins to the ubiquitination or proteasomal compartments [[cite:PMID:10051596], [cite:PMID:15601820]].
34 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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