Seroatlas · Human Serome Atlas

ASB13

Ankyrin repeat and SOCS box protein 13

Also known as: ASB13_HUMAN, FLJ13134, MGC19879

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WXK3
Gene: ASB13
Ensembl: ENSG00000196372
Chromosome: 10
Canonical length: 278 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants, both protein-coding and not protein-coding, have been described for this gene. [provided by RefSeq, Nov 2010]

Canonical amino-acid sequenceUniProt

278 residues, UniProt reviewed canonical sequence.

>Q8WXK3|ASB13
     1  MEPRAADGCF LGDVGFWVER TPVHEAAQRG ESLQLQQLIE SGACVNQVTV DSITPLHAAS
    61  LQGQARCVQL LLAAGAQVDA RNIDGSTPLC DACASGSIEC VKLLLSYGAK VNPPLYTASP
   121  LHEACMSGSS ECVRLLIDVG ANLEAHDCHF GTPLHVACAR EHLDCVKVLL NAGANVNAAK
   181  LHETALHHAA KVKNVDLIEM LIEFGGNIYA RDNRGKKPSD YTWSSSAPAK CFEYYEKTPL
   241  TLSQLCRVNL RKATGVRGLE KIAKLNIPPR LIDYLSYN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ASB13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 41 nTPM

Expression across tissuesHPA

Tissue

liver: 41 nTPM
duodenum: 24 nTPM
small intestine: 24 nTPM
kidney: 21 nTPM
adrenal gland: 19 nTPM
lymph node: 17 nTPM

Single-cell type

retinal pigment epithelial cells: 175 nCPM
retinal bipolar cells: 120 nCPM
hepatocytes: 101 nCPM
proximal tubule cells: 56 nCPM
enterocytes: 53 nCPM
rod photoreceptor cells: 52 nCPM

Immune cell

myeloid DC: 14 nTPM
classical monocyte: 13 nTPM
intermediate monocyte: 8.3 nTPM
total PBMC: 7.5 nTPM
non-classical monocyte: 6.6 nTPM
naive CD4 T-cell: 4.1 nTPM

Brain region

thalamus: 24 nTPM
cerebral cortex: 21 nTPM
cerebellum: 19 nTPM
midbrain: 19 nTPM
pons: 19 nTPM
medulla oblongata: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.78
gnomAD pLI: 0
gnomAD missense Z: 0.15
DepMap mean gene effect: 0.2
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

SOCS box domain
Ankyrin repeat
SOCS box-like domain superfamily
Ankyrin repeat-containing domain superfamily
Ankyrin repeat and SOCS box protein-like
SOCS box
Ankyrin repeats (3 copies)
Ankyrin repeats (many copies)
Ankyrin repeat and SOCS box protein 13, SOCS box domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ASB13 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ASB13 as an antibody target. Whether an autoantibody or antibody against ASB13 could matter depends on whether native ASB13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ASB13 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ASB13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...