Seroatlas · Human Serome Atlas

ASB16

Ankyrin repeat and SOCS box protein 16

Also known as: ASB16_HUMAN, FLJ30165

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96NS5
Gene: ASB16
Ensembl: ENSG00000161664
Chromosome: 17
Canonical length: 453 aa
Protein class: Predicted intracellular proteins
Subcellular location: Focal adhesion sites

OverviewNCBI Gene

The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

453 residues, UniProt reviewed canonical sequence.

>Q96NS5|ASB16
     1  MARETFPFTS SMLRSLRLQQ EWLEWEDRRR AAAQQCRSRR CPSSPRARLT RPHRSCRDPA
    61  VHQALFSGNL QQVQALFQDE EAANMIVETV SNQLAWSAEQ GFWVLTPKTK QTAPLAIATA
   121  RGYTDCARHL IRQGAELDAR VGGRAALHEA CARAQFDCVR LLLTFGAKAN VLTEEGTTPL
   181  HLCTIPESLQ CAKLLLEAGA TVNLAAGESQ ETPLHVAAAR GLEQHVALYL EHGADVGLRT
   241  SQGETALNTA CAGAEGPGSC RRHQAAARRL LEAGADARAA GRKRHTPLHN ACANGCGGLA
   301  ELLLRYGARA EVPNGAGHTP MDCALQAVQD SPNWEPEVLF AALLDYGAQP VRPEMLKHCA
   361  NFPRALEVLL NAYPCVPSCE TWVEAVLPEL WKEHEAFYSS ALCMVNQPRQ LQHLARLAVR
   421  ARLGSRCRQG ATRLPLPPLL RDYLLLRVEG CIQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ASB16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 63 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 63 nTPM
tongue: 12 nTPM
heart muscle: 4.3 nTPM
cerebellum: 3.7 nTPM
pancreas: 3.4 nTPM
lymph node: 3 nTPM

Single-cell type

myonuclei: 62 nCPM
epicardial cells: 30 nCPM
cardiomyocytes: 26 nCPM
thymic myoid cells: 19 nCPM
retinal ganglion cells: 16 nCPM
retinal horizontal cells: 14 nCPM

Immune cell

eosinophil: 5.8 nTPM
neutrophil: 4.1 nTPM
NK-cell: 2.6 nTPM
memory B-cell: 2.5 nTPM
basophil: 2.3 nTPM
naive CD4 T-cell: 2.3 nTPM

Brain region

cerebellum: 30 nTPM
midbrain: 14 nTPM
cerebral cortex: 13 nTPM
pons: 13 nTPM
white matter: 13 nTPM
medulla oblongata: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.59
gnomAD pLI: 0
gnomAD missense Z: -0.11
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ASB16 as an antibody target. Whether an autoantibody or antibody against ASB16 could matter depends on whether native ASB16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ASB16 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ASB16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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