Seroatlas · Human Serome Atlas

ASB17

Ankyrin repeat and SOCS box protein 17

Also known as: ASB17_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WXJ9
Gene: ASB17
Ensembl: ENSG00000154007
Chromosome: 1
Canonical length: 295 aa
Protein class: Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in intracellular signal transduction and protein ubiquitination. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

295 residues, UniProt reviewed canonical sequence.

>Q8WXJ9|ASB17
     1  MSKSTKLCGK TSCPRSNIFC NLLDKIVKRP SLQFLGQWGY HCYEPRIYRS LAKILRYVDL
    61  DGFDALLTDY IAFVEKSGYR FEVSFNLDFT EICVNTILYW VFARKGNPDF VELLLKKTKD
   121  YVQDRSCNLA LIWRTFTPVY CPSPLSGITP LFYVAQTRQS NIFKILLQYG ILEREKNPIN
   181  IVLTIVLYPS RVRVMVDREL ADIHEDAKTC LVLCSRVLSV ISVKEIKTQL SLGRHPIISN
   241  WFDYIPSTRY KDPCELLHLC RLTIRNQLLT NNMLPDGIFS LLIPARLQNY LNLEI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ASB17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 47 nTPM

Expression across tissuesHPA

Tissue

testis: 47 nTPM
kidney: 0.2 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

early spermatids: 1,285 nCPM
late spermatids: 473 nCPM
late primary spermatocytes: 345 nCPM
retinal horizontal cells: 26 nCPM
retinal ganglion cells: 12 nCPM
early primary spermatocytes: 5 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.8 nTPM
white matter: 0.7 nTPM
cerebellum: 0.6 nTPM
hippocampal formation: 0.6 nTPM
thalamus: 0.5 nTPM
basal ganglia: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.51
gnomAD pLI: 0
gnomAD missense Z: -0.12
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

intracellular signal transduction
protein polyubiquitination
spermatid cytoplasm removal during spermiation of flagellated sperm
cell-cell junction disassembly

Cellular components

cytosol
apical ectoplasmic specialization

Protein domainsUniProt · Pfam · InterPro

SOCS box domain
SOCS box-like domain superfamily
Ankyrin repeat-containing domain superfamily
SOCS box
Ankyrin repeat and SOCS box protein 17

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ASB17 as an antibody target. Whether an autoantibody or antibody against ASB17 could matter depends on whether native ASB17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ASB17 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ASB17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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