Seroatlas · Human Serome Atlas

SOCS1

Suppressor of cytokine signaling 1

Also known as: Cish1, JAB, SOCS-1, SOCS1_HUMAN, SSI-1, TIP3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O15524
Gene
SOCS1
Ensembl
ENSG00000185338
Chromosome
16
Canonical length
211 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Vesicles

OverviewNCBI Gene

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

211 residues, UniProt reviewed canonical sequence.

>O15524|SOCS1
     1  MVAHNQVAAD NAVSTAAEPR RRPEPSSSSS SSPAAPARPR PCPAVPAPAP GDTHFRTFRS
    61  HADYRRITRA SALLDACGFY WGPLSVHGAH ERLRAEPVGT FLVRDSRQRN CFFALSVKMA
   121  SGPTSIRVHF QAGRFHLDGS RESFDCLFEL LEHYVAAPRR MLGAPLRQRR VRPLQELCRQ
   181  RIVATVGREN LARIPLNPVL RDYLSSFPFQ I

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SOCS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
25 nTPM

Expression across tissuesHPA

Tissue

  • liver: 25 nTPM
  • spleen: 17 nTPM
  • kidney: 14 nTPM
  • pituitary gland: 14 nTPM
  • appendix: 14 nTPM
  • lymph node: 13 nTPM

Single-cell type

  • mast cells: 265 nCPM
  • pancreatic islet cells: 183 nCPM
  • innate lymphoid cells: 179 nCPM
  • epididymal basal cells: 140 nCPM
  • t-cells: 137 nCPM
  • nk-cells: 133 nCPM

Immune cell

  • basophil: 14 nTPM
  • eosinophil: 10 nTPM
  • NK-cell: 6.2 nTPM
  • naive B-cell: 5.4 nTPM
  • T-reg: 2.8 nTPM
  • memory CD8 T-cell: 2.6 nTPM

Brain region

  • cerebellum: 12 nTPM
  • pons: 6 nTPM
  • thalamus: 5.6 nTPM
  • medulla oblongata: 5.5 nTPM
  • hypothalamus: 4.8 nTPM
  • spinal cord: 3.6 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SOCS1.

Disease | AllUniProt

Conditions SOCS1 is implicated in, by any mechanism.

  • Autoinflammatory syndrome, familial, with or without immunodeficiency (AISIMD) MIM:619375

Disease | GeneticClinVar

13 pathogenic / likely-pathogenic of 94 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.07
gnomAD pLI
0.59
gnomAD missense Z
0.83
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SOCS1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SOCS1 as an antibody target. Whether an autoantibody or antibody against SOCS1 could matter depends on whether native SOCS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SOCS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SOCS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SOCS1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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