Seroatlas · Human Serome Atlas

ASB4

Ankyrin repeat and SOCS box protein 4

Also known as: ASB-4, ASB4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y574
Gene
ASB4
Ensembl
ENSG00000005981
Chromosome
7
Canonical length
426 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene but some of the full length sequences are not known. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

426 residues, UniProt reviewed canonical sequence.

>Q9Y574|ASB4
     1  MDGTTAPVTK SGAAKLVKRN FLEALKSNDF GKLKAILIQR QIDVDTVFEV EDENMVLASY
    61  KQGYWLPSYK LKSSWATGLH LSVLFGHVEC LLVLLDHNAT INCRPNGKTP LHVACEMANV
   121  DCVKILCDRG AKLNCYSLSG HTALHFCTTP SSILCAKQLV WRGANVNMKT NNQDEETPLH
   181  TAAHFGLSEL VAFYVEHGAI VDSVNAHMET PLAIAAYWAL RFKEQEYSTE HHLVCRMLLD
   241  YKAEVNARDD DFKSPLHKAA WNCDHVLMHM MLEAGAEANL MDINGCAAIQ YVLKVTSVRP
   301  AAQPEICYQL LLNHGAARIY PPQFHKVIQA CHSCPKAIEV VVNAYEHIRW NTKWRRAIPD
   361  DDLEKYWDFY HSLFTVCCNS PRTLMHLSRC AIRRTLHNRC HRAIPLLSLP LSLKKYLLLE
   421  PEGIIY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ASB4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
45 nTPM

Expression across tissuesHPA

Tissue

  • adrenal gland: 45 nTPM
  • skeletal muscle: 32 nTPM
  • tongue: 9.8 nTPM
  • pituitary gland: 7.9 nTPM
  • midbrain: 3.2 nTPM
  • spinal cord: 3 nTPM

Single-cell type

  • adrenal cortex cells: 191 nCPM
  • lactotrophs: 122 nCPM
  • late spermatids: 59 nCPM
  • somatotrophs: 51 nCPM
  • adrenal medulla cells: 43 nCPM
  • early spermatids: 37 nCPM

Immune cell

  • neutrophil: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • midbrain: 13 nTPM
  • medulla oblongata: 9.8 nTPM
  • pons: 9.8 nTPM
  • white matter: 9.8 nTPM
  • hypothalamus: 9.2 nTPM
  • basal ganglia: 9.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.41
gnomAD pLI
0
gnomAD missense Z
-0.52
DepMap mean gene effect
0.14
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ASB4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ASB4 as an antibody target. Whether an autoantibody or antibody against ASB4 could matter depends on whether native ASB4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ASB4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ASB4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ASB4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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