Seroatlas · Human Serome Atlas

ASB15

Ankyrin repeat and SOCS box protein 15

Also known as: ASB15_HUMAN, FLJ43370

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WXK1
Gene: ASB15
Ensembl: ENSG00000146809
Chromosome: 7
Canonical length: 588 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the suppressor of cytokine signaling box superfamily. The proteins in this superfamily participate in the ubiquitin-proteasome system for the degradation of proteins in the cell cycle and signal transduction pathways. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Canonical amino-acid sequenceUniProt

588 residues, UniProt reviewed canonical sequence.

>Q8WXK1|ASB15
     1  MDTNDDPDED HLTSYDIQLS IQESIEASKT ALCPERFVPL SAQNRKLVEA IKQGHIPELQ
    61  EYVKYKYAMD EADEKGWFPL HEAVVQPIQQ ILEIVLDASY KTLWEFKTCD GETPLTLAVK
   121  AGLVENVRTL LEKGVWPNTK NDKGETPLLI AVKKGSYDMV STLIKHNTSL DQPCVKRWSA
   181  MHEAAKQGRK DIVALLLKHG GNVHLRDGFG VTPLGVAAEY GHCDVLEHLI HKGGDVLALA
   241  DDGASVLFEA AGGGNPDCIS LLLEYGGSGN VPNRAGHLPI HRAAYEGHYL ALKYLIPVTS
   301  KNAIRKSGLT PIHSAADGQN AQCLELLIEN GFDVNTLLAD HISQSYDDER KTALYFGVSN
   361  NDVHCTEVLL AAGADPNLDP LNCLLVAVRA NNYEIVRLLL SHGANVNCYF MHVNDTRFPS
   421  VIQYALNDEV MLRLLLNNGY QVEMCFDCMH GDIFGNSFVW SEIQEEVLPG WTSCVIKDNP
   481  FCEFITVPWM KHLVGRVTRV LIDYMDYVPL CAKLKSALEV QREWPEIRQI LENPCSLKHL
   541  CRLKIRRLMG LQKLCQPASV EKLPLPPAIQ RYILFKEYDL YGQELKLT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ASB15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 112 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 112 nTPM
tongue: 79 nTPM
heart muscle: 26 nTPM
kidney: 6.9 nTPM
testis: 2.1 nTPM
esophagus: 1 nTPM

Single-cell type

myonuclei: 440 nCPM
cardiomyocytes: 413 nCPM
early spermatids: 96 nCPM
late primary spermatocytes: 82 nCPM
adipocytes: 14 nCPM
thymic myoid cells: 11 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 0.5 nTPM
cerebral cortex: 0.4 nTPM
midbrain: 0.4 nTPM
hippocampal formation: 0.3 nTPM
white matter: 0.3 nTPM
hypothalamus: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.29
gnomAD pLI: 0
gnomAD missense Z: 0.55
DepMap mean gene effect: 0.22
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ASB15 as an antibody target. Whether an autoantibody or antibody against ASB15 could matter depends on whether native ASB15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ASB15 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ASB15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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