Seroatlas · Human Serome Atlas

NEURL2

Neuralized-like protein 2

Also known as: C20orf163, dJ337O18.6, FLJ30259, NEUL2_HUMAN, Ozz, Ozz-E3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BR09
Gene: NEURL2
Ensembl: ENSG00000124257
Chromosome: 20
Canonical length: 285 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

This gene encodes a protein that is involved in the regulation of myofibril organization. This protein is likely the adaptor component of the E3 ubiquitin ligase complex in striated muscle, and it regulates the ubiquitin-mediated degradation of beta-catenin during myogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2013]

Canonical amino-acid sequenceUniProt

285 residues, UniProt reviewed canonical sequence.

>Q9BR09|NEURL2
     1  MAAASEPVDS GALWGLERPE PPPTRFHRVH GANIRVDPSG TRATRVESFA HGVCFSREPL
    61  APGQVFLVEI EEKELGWCGH LRLGLTALDP ASLAPVPEFS LPDLVNLGHT WVFAITRHHN
   121  RVPREGRPEA EAAAPSRPPT LLVEPYLRIE QFRIPRDRLV GRSRPGLYSH LLDQLYELNV
   181  LPPTARRSRL GVLFCPRPDG TADMHIIING EDMGPSARGL PAAQPLYAVV DVFASTKSVR
   241  LVQLEYGLPS LQTLCRLVIQ RSMVHRLAID GLHLPKELKD FCKYE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NEURL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

kidney: 25 nTPM
skeletal muscle: 18 nTPM
adipose tissue: 14 nTPM
ovary: 9.5 nTPM
blood vessel: 9.2 nTPM
adrenal gland: 8.9 nTPM

Single-cell type

hofbauer cells: 62 nCPM
kupffer cells: 34 nCPM
epididymal basal cells: 20 nCPM
macrophages: 17 nCPM
late spermatids: 16 nCPM
myonuclei: 15 nCPM

Immune cell

memory B-cell: 2.9 nTPM
eosinophil: 1.8 nTPM
naive CD4 T-cell: 1.5 nTPM
naive CD8 T-cell: 1.3 nTPM
naive B-cell: 1 nTPM
NK-cell: 1 nTPM

Brain region

cerebellum: 15 nTPM
choroid plexus: 15 nTPM
cerebral cortex: 13 nTPM
white matter: 12 nTPM
basal ganglia: 11 nTPM
pons: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.71
gnomAD pLI: 0
gnomAD missense Z: 0.31
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ubiquitin protein ligase activity

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NEURL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CTNNB1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NEURL2 as an antibody target. Whether an autoantibody or antibody against NEURL2 could matter depends on whether native NEURL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NEURL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NEURL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...