Seroatlas · Human Serome Atlas

ASB18

Ankyrin repeat and SOCS box protein 18

Also known as: ASB18_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZVZ8
Gene: ASB18
Ensembl: ENSG00000182177
Chromosome: 2
Canonical length: 466 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoli,Mitochondria

OverviewNCBI Gene

The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. [provided by RefSeq, Feb 2017]

Canonical amino-acid sequenceUniProt

466 residues, UniProt reviewed canonical sequence.

>Q6ZVZ8|ASB18
     1  MSNSDYLPDY PLNSDLVKRL KSALDAKDEE RVRDLICTEI TPVDAVIELA NDDWMKDPSA
    61  QLPTGMLLGD LDHLKPLMDQ FFQDANVVFE INKDEMEWQV KSPATFGLSG LWTLEYKREL
   121  TTPLCIAAAH GHTACVRHLL GRGADPDASP GGRGALHEAC LGGHTACVRL LLQHRADPDL
   181  LSAEGLAPLH LCRTAASLGC AQALLEHGAS VQRVGGTGRD TPLHVAAQRG LDEHARLYLG
   241  RGAHVDARNG RGETALSAAC GAARRPDEHG RCLRLCALLL RRGAEADARD EDERSPLHKA
   301  CGHASHSLAR LLLRHGADAG ALDYGGASPL GRVLQTASCA LQASPQRTVQ ALLNHGSPTV
   361  WPDAFPKVLK TCASVPAVIE VLFNSYPQLC LSESWKEVIP EEVFQMHKPF YQSLFALALT
   421  PRCLQHLCRC ALRRLFGKRC FDLIPLLPLP KPLQNYLLLE PQGVLH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ASB18 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 11 nTPM
heart muscle: 6.6 nTPM
tongue: 1.5 nTPM
basal ganglia: 0.6 nTPM
testis: 0.5 nTPM
cerebral cortex: 0.2 nTPM

Single-cell type

myonuclei: 277 nCPM
cardiomyocytes: 93 nCPM
bergmann glia: 45 nCPM
corticotrophs: 19 nCPM
loop of henle epithelial cells: 16 nCPM
brain inhibitory neurons: 13 nCPM

Immune cell

neutrophil: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

basal ganglia: 12 nTPM
thalamus: 8.1 nTPM
medulla oblongata: 6.2 nTPM
midbrain: 6.1 nTPM
spinal cord: 5.2 nTPM
pons: 4.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.64
gnomAD pLI: 0
gnomAD missense Z: 0.61
DepMap mean gene effect: 0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ASB18 as an antibody target. Whether an autoantibody or antibody against ASB18 could matter depends on whether native ASB18 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ASB18 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ASB18 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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