Seroatlas · Human Serome Atlas

ASB5

Ankyrin repeat and SOCS box protein 5

Also known as: ASB5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WWX0
Gene: ASB5
Ensembl: ENSG00000164122
Chromosome: 4
Canonical length: 329 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Plasma membrane

OverviewNCBI Gene

The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene but their full length sequences are not known. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

329 residues, UniProt reviewed canonical sequence.

>Q8WWX0|ASB5
     1  MSVLEENRPF AQQLSNVYFT ILSLFCFKLF VKISLAILSH FYIVKGNRKE AARIAAEFYG
    61  VTQGQGSWAD RSPLHEAASQ GRLLALRTLL SQGYNVNAVT LDHVTPLHEA CLGDHVACAR
   121  TLLEAGANVN AITIDGVTPL FNACSQGSPS CAELLLEYGA KAQLESCLPS PTHEAASKGH
   181  HECLDILISW GIDVDQEIPH LGTPLYVACM SQQFHCIWKL LYAGADVQKG KYWDTPLHAA
   241  AQQSSTEIVN LLLEFGADIN AKNTELLRPI DVATSSSMVE RILLQHEATP SSLYQLCRLC
   301  IRSYIGKPRL HLIPQLQLPT LLKNFLQYR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ASB5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 203 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 203 nTPM
tongue: 63 nTPM
salivary gland: 23 nTPM
urinary bladder: 20 nTPM
prostate: 12 nTPM
colon: 10 nTPM

Single-cell type

myonuclei: 1,830 nCPM
late spermatids: 527 nCPM
thymic myoid cells: 377 nCPM
myosatellite cells: 133 nCPM
smooth muscle cells: 107 nCPM
early spermatids: 79 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

midbrain: 3 nTPM
cerebellum: 2.3 nTPM
white matter: 2 nTPM
cerebral cortex: 1.9 nTPM
medulla oblongata: 1.7 nTPM
pons: 1.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.5
gnomAD pLI: 0
gnomAD missense Z: -0.22
DepMap mean gene effect: 0.19
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

SOCS box domain
Ankyrin repeat
SOCS box-like domain superfamily
Ankyrin repeat-containing domain superfamily
Ankyrin repeat and SOCS box protein-like
SOCS box
Ankyrin repeats (3 copies)
Ankyrin repeat and SOCS box protein 5, SOCS box domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ASB5 as an antibody target. Whether an autoantibody or antibody against ASB5 could matter depends on whether native ASB5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ASB5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ASB5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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