Seroatlas · Human Serome Atlas

ASB2

Ankyrin repeat and SOCS box protein 2

Also known as: ASB-2, ASB2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96Q27
Gene: ASB2
Ensembl: ENSG00000100628
Chromosome: 14
Canonical length: 635 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli fibrillar center,Cytosol

OverviewNCBI Gene

This gene encodes a member of the ankyrin repeat and SOCS box-containing (ASB) protein family. These proteins play a role in protein degradation by coupling suppressor of cytokine signalling (SOCS) proteins with the elongin BC complex. The encoded protein is a subunit of a multimeric E3 ubiquitin ligase complex that mediates the degradation of actin-binding proteins. This gene plays a role in retinoic acid-induced growth inhibition and differentiation of myeloid leukemia cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

Canonical amino-acid sequenceUniProt

635 residues, UniProt reviewed canonical sequence.

>Q96Q27|ASB2
     1  MATQISTRGS QCTIGQEEYS LYSSLSEDEL VQMAIEQSLA DKTRGPTTAE ATASACTNRQ
    61  PAHFYPWTRS TAPPESSPAR APMGLFQGVM QKYSSSLFKT SQLAPADPLI KAIKDGDEEA
   121  LKTMIKEGKN LAEPNKEGWL PLHEAAYYGQ VGCLKVLQRA YPGTIDQRTL QEETAVYLAT
   181  CRGHLDCLLS LLQAGAEPDI SNKSRETPLY KACERKNAEA VKILVQHNAD TNHRCNRGWT
   241  ALHESVSRND LEVMQILVSG GAKVESKNAY GITPLFVAAQ SGQLEALRFL AKYGADINTQ
   301  ASDNASALYE ACKNEHEEVV EFLLSQGADA NKTNKDGLLP LHIASKKGNY RIVQMLLPVT
   361  SRTRIRRSGV SPLHLAAERN HDEVLEALLS ARFDVNTPLA PERARLYEDR RSSALYFAVV
   421  NNNVYATELL LQHGADPNRD VISPLLVAIR HGCLRTMQLL LDHGANIDAY IATHPTAFPA
   481  TIMFAMKCLS LLKFLMDLGC DGEPCFSCLY GNGPHPPAPQ PSSRFNDAPA ADKEPSVVQF
   541  CEFVSAPEVS RWAGPIIDVL LDYVGNVQLC SRLKEHIDSF EDWAVIKEKA EPPRPLAHLC
   601  RLRVRKAIGK YRIKLLDTLP LPGRLIRYLK YENTQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ASB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 495 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 495 nTPM
tongue: 147 nTPM
heart muscle: 81 nTPM
colon: 66 nTPM
urinary bladder: 37 nTPM
fallopian tube: 35 nTPM

Single-cell type

cardiomyocytes: 11 nCPM
vascular smooth muscle cells: 3.4 nCPM
myonuclei: 3 nCPM
microglia: 2.4 nCPM
epicardial cells: 2.3 nCPM
brain excitatory neurons: 1.6 nCPM

Immune cell

eosinophil: 51 nTPM
non-classical monocyte: 7.8 nTPM
myeloid DC: 4.2 nTPM
memory CD8 T-cell: 3.8 nTPM
intermediate monocyte: 2.7 nTPM
T-reg: 2.3 nTPM

Brain region

basal ganglia: 5.7 nTPM
cerebral cortex: 5.3 nTPM
thalamus: 2.1 nTPM
pons: 1.9 nTPM
white matter: 1.8 nTPM
medulla oblongata: 1.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.22
gnomAD pLI: 0
gnomAD missense Z: 0.39
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

cullin family protein binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

SOCS box domain
Ankyrin repeat
SOCS box-like domain superfamily
Ankyrin repeat-containing domain superfamily
SOCS box
Ankyrin repeats (3 copies)
Ankyrin repeat
Ankyrin repeats (many copies)
Ankyrin repeat and SOCS box protein 2, SOCS box domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ASB2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ASB2 as an antibody target. Whether an autoantibody or antibody against ASB2 could matter depends on whether native ASB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ASB2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ASB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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