Seroatlas · Human Serome Atlas

SOCS5

Suppressor of cytokine signaling 5

Also known as: CIS6, Cish5, CISH6, KIAA0671, SOCS-5, SOCS5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75159
Gene: SOCS5
Ensembl: ENSG00000171150
Chromosome: 2
Canonical length: 536 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

536 residues, UniProt reviewed canonical sequence.

>O75159|SOCS5
     1  MDKVGKMWNN FKYRCQNLFG HEGGSRSENV DMNSNRCLSV KEKNISIGDS TPQQQSSPLR
    61  ENIALQLGLS PSKNSSRRNQ NCATEIPQIV EISIEKDNDS CVTPGTRLAR RDSYSRHAPW
   121  GGKKKHSCST KTQSSLDADK KFGRTRSGLQ RRERRYGVSS VHDMDSVSSR TVGSRSLRQR
   181  LQDTVGLCFP MRTYSKQSKP LFSNKRKIHL SELMLEKCPF PAGSDLAQKW HLIKQHTAPV
   241  SPHSTFFDTF DPSLVSTEDE EDRLRERRRL SIEEGVDPPP NAQIHTFEAT AQVNPLYKLG
   301  PKLAPGMTEI SGDSSAIPQA NCDSEEDTTT LCLQSRRQKQ RQISGDSHTH VSRQGAWKVH
   361  TQIDYIHCLV PDLLQITGNP CYWGVMDRYE AEALLEGKPE GTFLLRDSAQ EDYLFSVSFR
   421  RYNRSLHARI EQWNHNFSFD AHDPCVFHSS TVTGLLEHYK DPSSCMFFEP LLTISLNRTF
   481  PFSLQYICRA VICRCTTYDG IDGLPLPSML QDFLKEYHYK QKVRVRWLER EPVKAK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SOCS5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

ovary: 22 nTPM
cerebellum: 20 nTPM
tongue: 15 nTPM
parathyroid gland: 13 nTPM
endometrium: 13 nTPM
smooth muscle: 13 nTPM

Single-cell type

podocytes: 51 nCPM
distal convoluted tubule cells: 50 nCPM
loop of henle epithelial cells: 45 nCPM
renal collecting duct intercalated cells: 40 nCPM
renal connecting tubule cells: 40 nCPM
proximal tubule cells: 40 nCPM

Immune cell

naive B-cell: 3 nTPM
eosinophil: 2.5 nTPM
memory B-cell: 1.8 nTPM
non-classical monocyte: 1.8 nTPM
naive CD8 T-cell: 1.5 nTPM
MAIT T-cell: 1.1 nTPM

Brain region

cerebellum: 36 nTPM
spinal cord: 21 nTPM
pons: 21 nTPM
white matter: 21 nTPM
medulla oblongata: 20 nTPM
midbrain: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.47
gnomAD pLI: 0.54
gnomAD missense Z: 0.69
DepMap mean gene effect: -0.22
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SOCS5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SOCS5 as an antibody target. Whether an autoantibody or antibody against SOCS5 could matter depends on whether native SOCS5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SOCS5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SOCS5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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