Seroatlas · Human Serome Atlas

ASB14

Ankyrin repeat and SOCS box protein 14

Also known as: ASB14_HUMAN, DKFZp313L0121

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NK59
Gene: ASB14
Ensembl: ENSG00000239388
Chromosome: 3
Canonical length: 587 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Dec 2008]

Canonical amino-acid sequenceUniProt

587 residues, UniProt reviewed canonical sequence.

>A6NK59|ASB14
     1  MDNYTSDEDI DEDFDTQLII QQSLQDIYKP GTAQHAPKDE SLHSFLSADY KKIVETIEKV
    61  GKEDALSHLT KYHSAFGEAD EIGWIPLHKA AVQLNRKILE ITLSASDPSL WEQTTHNGET
   121  PLFLAVSSCL LENATFLLLN GCNPNAKNFE GNSPLLAAVL RDCYDMAALL INYGADVNLR
   181  CANERTALHE AAKLGREDMV KLMLVSGAHP DPQSTYGFTP LALAAQSGHT EIMEMLLRKG
   241  KIFCLASDSS SILLEAASGG NPDAVALLLE YGADANIPKN SGHLPIHVAA DRGHLLALKI
   301  LIPVTDLAAI KQSGISPVHC AAAGAHPQCL ELLIQAGFDV NFMLDQRINK HYDDHRKSAL
   361  YFAVSNSDLS SVKLLLSAGA LPNQDPVNCL QIALRMGNYE LISLLLRHGA NVNYFCRVNP
   421  LHFPSALQYT LKDEVMLRML LNYGYDTERC FDCPHGDKVH PSYTVEGWTS TVIKDTKFCE
   481  VITLSWLQHL SGKVVRVMLD YVDQVRICSK LKAVLQKQGI WSEIHFILTN PRSLKHLCRL
   541  KIRKCMGRLH LRCPVFMSFL PLPNRLKAYV LYKEYDLYGQ GIFTGTW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ASB14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 26 nTPM
tongue: 17 nTPM
heart muscle: 3.6 nTPM
bone marrow: 1.8 nTPM
pancreas: 1.5 nTPM
retina: 1.5 nTPM

Single-cell type

myonuclei: 213 nCPM
cardiomyocytes: 178 nCPM
respiratory ciliated cells: 117 nCPM
epicardial cells: 68 nCPM
ependymal cells: 67 nCPM
rod photoreceptor cells: 41 nCPM

Immune cell

naive B-cell: 0.3 nTPM
plasmacytoid DC: 0.2 nTPM
memory B-cell: 0.1 nTPM
naive CD4 T-cell: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM

Brain region

cerebellum: 4.9 nTPM
medulla oblongata: 3.4 nTPM
white matter: 3.1 nTPM
pons: 3 nTPM
spinal cord: 3 nTPM
choroid plexus: 2.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.69
gnomAD pLI: 0
gnomAD missense Z: 0.42
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ASB14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

MAPRE2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ASB14 as an antibody target. Whether an autoantibody or antibody against ASB14 could matter depends on whether native ASB14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ASB14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ASB14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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