Seroatlas · Human Serome Atlas

SOCS7

Suppressor of cytokine signaling 7

Also known as: NAP4, NCKAP4, SOCS7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O14512
Gene
SOCS7
Ensembl
ENSG00000274211
Chromosome
17
Canonical length
581 aa
Protein class
Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

Predicted to enable phosphorylation-dependent protein binding activity; signaling adaptor activity; and ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in insulin receptor signaling pathway; proteasome-mediated ubiquitin-dependent protein catabolic process; and regulation of neuron migration. Predicted to act upstream of or within brain development; fat cell differentiation; and protein ubiquitination. Located in cytosol. Is active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

581 residues, UniProt reviewed canonical sequence.

>O14512|SOCS7
     1  MVFRNVGRPP EEEDVEAAPE PGPSELLCPR HRCALDPKAL PPGLALERTW GPAAGLEAQL
    61  AALGLGQPAG PGVKTVGGGC CPCPCPPQPP PPQPQPPAAA PQAGEDPTET SDALLVLEGL
   121  ESEAESLETN SCSEEELSSP GRGGGGGGRL LLQPPGPELP PVPFPLQDLV PLGRLSRGEQ
   181  QQQQQQQPPP PPPPPGPLRP LAGPSRKGSF KIRLSRLFRT KSCNGGSGGG DGTGKRPSGE
   241  LAASAASLTD MGGSAGRELD AGRKPKLTRT QSAFSPVSFS PLFTGETVSL VDVDISQRGL
   301  TSPHPPTPPP PPRRSLSLLD DISGTLPTSV LVAPMGSSLQ SFPLPPPPPP HAPDAFPRIA
   361  PIRAAESLHS QPPQHLQCPL YRPDSSSFAA SLRELEKCGW YWGPMNWEDA EMKLKGKPDG
   421  SFLVRDSSDP RYILSLSFRS QGITHHTRME HYRGTFSLWC HPKFEDRCQS VVEFIKRAIM
   481  HSKNGKFLYF LRSRVPGLPP TPVQLLYPVS RFSNVKSLQH LCRFRIRQLV RIDHIPDLPL
   541  PKPLISYIRK FYYYDPQEEV YLSLKEAQLI SKQKQEVEPS T

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SOCS7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.59
Highest tissue expression
69 nTPM

Expression across tissuesHPA

Tissue

  • testis: 69 nTPM
  • cerebellum: 43 nTPM
  • pancreas: 14 nTPM
  • skeletal muscle: 13 nTPM
  • retina: 12 nTPM
  • cerebral cortex: 11 nTPM

Single-cell type

  • late spermatids: 569 nCPM
  • early spermatids: 238 nCPM
  • brain excitatory neurons: 75 nCPM
  • choroid plexus epithelial cells: 53 nCPM
  • late primary spermatocytes: 48 nCPM
  • brain inhibitory neurons: 47 nCPM

Immune cell

  • gdT-cell: 0.3 nTPM
  • MAIT T-cell: 0.3 nTPM
  • classical monocyte: 0.1 nTPM
  • intermediate monocyte: 0.1 nTPM
  • memory B-cell: 0.1 nTPM
  • memory CD4 T-cell: 0.1 nTPM

Brain region

  • cerebellum: 66 nTPM
  • hippocampal formation: 37 nTPM
  • cerebral cortex: 36 nTPM
  • basal ganglia: 34 nTPM
  • amygdala: 32 nTPM
  • thalamus: 29 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SOCS7.

Disease | ImmuneIEDB

Conditions an epitope on SOCS7 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.23
gnomAD pLI
1
gnomAD missense Z
2.1
DepMap mean gene effect
0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SOCS7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SOCS7 as an antibody target. Whether an autoantibody or antibody against SOCS7 could matter depends on whether native SOCS7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SOCS7 is annotated at the cell surface, where native SOCS7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SOCS7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SOCS7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...