Seroatlas · Human Serome Atlas

SOCS6

Suppressor of cytokine signaling 6

Also known as: CIS4, Cish4, HSPC060, SOCS4, SOCS6_HUMAN, SSI4, STAI4, STATI4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O14544
Gene: SOCS6
Ensembl: ENSG00000170677
Chromosome: 18
Canonical length: 535 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles,Cytosol

OverviewNCBI Gene

The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

535 residues, UniProt reviewed canonical sequence.

>O14544|SOCS6
     1  MKKISLKTLR KSFNLNKSKE ETDFMVVQQP SLASDFGKDD SLFGSCYGKD MASCDINGED
    61  EKGGKNRSKS ESLMGTLKRR LSAKQKSKGK AGTPSGSSAD EDTFSSSSAP IVFKDVRAQR
   121  PIRSTSLRSH HYSPAPWPLR PTNSEETCIK MEVRVKALVH SSSPSPALNG VRKDFHDLQS
   181  ETTCQEQANS LKSSASHNGD LHLHLDEHVP VVIGLMPQDY IQYTVPLDEG MYPLEGSRSY
   241  CLDSSSPMEV SAVPPQVGGR AFPEDESQVD QDLVVAPEIF VDQSVNGLLI GTTGVMLQSP
   301  RAGHDDVPPL SPLLPPMQNN QIQRNFSGLT GTEAHVAESM RCHLNFDPNS APGVARVYDS
   361  VQSSGPMVVT SLTEELKKLA KQGWYWGPIT RWEAEGKLAN VPDGSFLVRD SSDDRYLLSL
   421  SFRSHGKTLH TRIEHSNGRF SFYEQPDVEG HTSIVDLIEH SIRDSENGAF CYSRSRLPGS
   481  ATYPVRLTNP VSRFMQVRSL QYLCRFVIRQ YTRIDLIQKL PLPNKMKDYL QEKHY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SOCS6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

liver: 26 nTPM
small intestine: 21 nTPM
colon: 15 nTPM
duodenum: 15 nTPM
cervix: 14 nTPM
esophagus: 14 nTPM

Single-cell type

microglia: 554 nCPM
melanocytes: 135 nCPM
ocular epithelial cells: 102 nCPM
esophageal apical cells: 99 nCPM
foveolar cells: 97 nCPM
syncytiotrophoblasts: 86 nCPM

Immune cell

myeloid DC: 3.9 nTPM
classical monocyte: 3.6 nTPM
eosinophil: 2.9 nTPM
total PBMC: 1.2 nTPM
NK-cell: 1 nTPM
intermediate monocyte: 0.7 nTPM

Brain region

white matter: 49 nTPM
thalamus: 45 nTPM
medulla oblongata: 39 nTPM
pons: 37 nTPM
spinal cord: 36 nTPM
cerebellum: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.22
gnomAD pLI: 0.99
gnomAD missense Z: 0.85
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

signaling adaptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SOCS6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SOCS6 as an antibody target. Whether an autoantibody or antibody against SOCS6 could matter depends on whether native SOCS6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SOCS6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SOCS6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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