ASB11

Protein identityUniProt · HPA

UniProt accession

Q8WXH4

Gene

ASB11

Ensembl

ENSG00000165192

Chromosome

X

Canonical length

323 aa

Protein class

Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

Canonical amino-acid sequenceUniProt

323 residues, UniProt reviewed canonical sequence.

>Q8WXH4|ASB11
     1  MEDGPVFYGF KNIFITMFAT FFFFKLLIKV FLALLTHFYI VKGNRKEAAR IAEEIYGGIS
    61  DCWADRSPLH EAAAQGRLLA LKTLIAQGVN VNLVTINRVS SLHEACLGGH VACAKALLEN
   121  GAHVNGVTVH GATPLFNACC SGSAACVNVL LEFGAKAQLE VHLASPIHEA VKRGHRECME
   181  ILLANNVNID HEVPQLGTPL YVACTYQRVD CVKKLLELGA SVDHGQWLDT PLHAAARQSN
   241  VEVIHLLTDY GANLKRRNAQ GKSALDLAAP KSSVEQALLL REGPPALSQL CRLCVRKCLG
   301  RACHQAIHKL HLPEPLERFL LYQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ASB11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.3

Highest tissue expression

107 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.61

gnomAD pLI

0

gnomAD missense Z

0

DepMap mean gene effect

0.18

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• endoplasmic reticulum unfolded protein response
• positive regulation of protein catabolic process
• proteasome-mediated ubiquitin-dependent protein catabolic process
• protein K11-linked ubiquitination
• protein ubiquitination

Molecular functions

• ubiquitin-like ligase-substrate adaptor activity

Cellular components

• Cul5-RING ubiquitin ligase complex
• cytosol
• endoplasmic reticulum

Protein domainsUniProt · Pfam · InterPro

• SOCS box domain
• Ankyrin repeat
• SOCS box-like domain superfamily
• Ankyrin repeat-containing domain superfamily
• Ankyrin repeat and SOCS box protein 9/11, SOCS box domain
• Ankyrin repeat and SOCS box protein-like
• SOCS box
• Ankyrin repeats (3 copies)

KeywordsUniProt

• ANK repeat
• Endoplasmic reticulum
• Repeat
• Ubl conjugation pathway