Seroatlas · Human Serome Atlas

ASB3

Ankyrin repeat and SOCS box protein 3

Also known as: ASB-3, ASB3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y575
Gene: ASB3
Ensembl: ENSG00000115239
Chromosome: 2
Canonical length: 518 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2011]

Canonical amino-acid sequenceUniProt

518 residues, UniProt reviewed canonical sequence.

>Q9Y575|ASB3
     1  MDFTEAYADT CSTVGLAARE GNVKVLRKLL KKGRSVDVAD NRGWMPIHEA AYHNSVECLQ
    61  MLINADSSEN YIKMKTFEGF CALHLAASQG HWKIVQILLE AGADPNATTL EETTPLFLAV
   121  ENGQIDVLRL LLQHGANVNG SHSMCGWNSL HQASFQENAE IIKLLLRKGA NKECQDDFGI
   181  TPLFVAAQYG KLESLSILIS SGANVNCQAL DKATPLFIAA QEGHTKCVEL LLSSGADPDL
   241  YCNEDSWQLP IHAAAQMGHT KILDLLIPLT NRACDTGLNK VSPVYSAVFG GHEDCLEILL
   301  RNGYSPDAQA CLVFGFSSPV CMAFQKDCEF FGIVNILLKY GAQINELHLA YCLKYEKFSI
   361  FRYFLRKGCS LGPWNHIYEF VNHAIKAQAK YKEWLPHLLV AGFDPLILLC NSWIDSVSID
   421  TLIFTLEFTN WKTLAPAVER MLSARASNAW ILQQHIATVP SLTHLCRLEI RSSLKSERLR
   481  SDSYISQLPL PRSLHNYLLY EDVLRMYEVP ELAAIQDG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ASB3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

midbrain: 22 nTPM
retina: 21 nTPM
basal ganglia: 21 nTPM
amygdala: 21 nTPM
cerebral cortex: 20 nTPM
hypothalamus: 18 nTPM

Single-cell type

astrocytes: 875 nCPM
oligodendrocyte progenitor cells: 498 nCPM
ependymal cells: 415 nCPM
bergmann glia: 403 nCPM
thyrotrophs: 339 nCPM
cardiomyocytes: 325 nCPM

Immune cell

basophil: 17 nTPM
eosinophil: 13 nTPM
MAIT T-cell: 13 nTPM
memory B-cell: 12 nTPM
T-reg: 12 nTPM
naive CD8 T-cell: 11 nTPM

Brain region

cerebral cortex: 108 nTPM
cerebellum: 105 nTPM
basal ganglia: 99 nTPM
amygdala: 98 nTPM
midbrain: 98 nTPM
white matter: 98 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.9
gnomAD pLI: 0
gnomAD missense Z: -0.27
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

SOCS box domain
Ankyrin repeat
SOCS box-like domain superfamily
Ankyrin repeat-containing domain superfamily
Ankyrin repeat
SOCS box
Ankyrin repeats (3 copies)
Ankyrin repeat and SOCS box protein 3, SOCS box domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ASB3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ASB3 as an antibody target. Whether an autoantibody or antibody against ASB3 could matter depends on whether native ASB3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ASB3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ASB3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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