Seroatlas · Human Serome Atlas

ASB10

Ankyrin repeat and SOCS box protein 10

Also known as: ASB10_HUMAN, GLC1F

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WXI3
Gene
ASB10
Ensembl
ENSG00000146926
Chromosome
7
Canonical length
467 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. The SOCS box serves to couple suppressor of cytokine signaling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2008]

Canonical amino-acid sequenceUniProt

467 residues, UniProt reviewed canonical sequence.

>Q8WXI3|ASB10
     1  MLMSWSPEEC KGQGEPLDDR HPLCARLVEK PSRGSEEHLK SGPGPIVTRT ASGPALAFWQ
    61  AVLAGDVGCV SRILADSSTG LAPDSVFDTS DPERWRDFRF NIRALRLWSL TYEEELTTPL
   121  HVAASRGHTE VLRLLLRRRA RPDSAPGGRT ALHEACAAGH TACVHVLLVA GADPNIADQD
   181  GKRPLHLCRG PGTLECAELL LRFGARVDGR SEEEEETPLH VAARLGHVEL ADLLLRRGAC
   241  PDARNAEGWT PLLAACDVRC QSITDAEATT ARCLQLCSLL LSAGADADAA DQDKQRPLHL
   301  ACRRGHAAVV ELLLSCGVSA NTMDYGGHTP LHCALQGPAA ALAQSPEHVV RALLNHGAVR
   361  VWPGALPKVL ERWSTCPRTI EVLMNTYSVV QLPEEAVGLV TPETLQKHQR FYSSLFALVR
   421  QPRSLQHLSR CALRSHLEGS LPQALPRLPL PPRLLRYLQL DFEGVLY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ASB10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
73 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 73 nTPM
  • heart muscle: 25 nTPM
  • tongue: 13 nTPM
  • salivary gland: 0.9 nTPM
  • blood vessel: 0.7 nTPM
  • esophagus: 0.4 nTPM

Single-cell type

  • myonuclei: 132 nCPM
  • cardiomyocytes: 92 nCPM
  • thymic myoid cells: 15 nCPM
  • vascular smooth muscle cells: 3.3 nCPM
  • adipocytes: 2.4 nCPM
  • epicardial cells: 2.3 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 0.1 nTPM
  • hypothalamus: 0.1 nTPM
  • medulla oblongata: 0.1 nTPM
  • spinal cord: 0.1 nTPM
  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ASB10.

Disease | AllUniProt

Conditions ASB10 is implicated in, by any mechanism.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.62
gnomAD pLI
0
gnomAD missense Z
-0.32
DepMap mean gene effect
0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ASB10 as an antibody target. Whether an autoantibody or antibody against ASB10 could matter depends on whether native ASB10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ASB10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ASB10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ASB10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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