Core Histone H2A/H2B/H3 domain
IPR007125
Definition
Five major families of histones exist: H1/H5, H2A, H2B, H3, and H4 PMID:16472024. Histones H2A, H2B, H3 and H4 are known as the core histones, while histones H1 and H5 are known as the linker histones. The core histones together with some other DNA binding proteins form a superfamily defined by a common fold and distant sequence similarities [[cite:PMID:7651829], [cite:PMID:9016552]]. Some proteins contain local homology domains related to the histone fold PMID:9305837. This entry represents a domain found in histones H2A, H2B and H3. This domain can also be found in transcription factors, such as OsNF-YC2 from rice PMID:26542958.
47 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
Loading the interactive Seroatlas explorer...