Seroatlas · Human Serome Atlas

H2BC15

Histone H2B type 1-N

Also known as: H2B/d, H2B1N_HUMAN, H2BFD, HIST1H2BN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q99877
Gene
H2BC15
Ensembl
ENSG00000233822
Chromosome
6
Canonical length
126 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]

Canonical amino-acid sequenceUniProt

126 residues, UniProt reviewed canonical sequence.

>Q99877|H2BC15
     1  MPEPSKSAPA PKKGSKKAVT KAQKKDGKKR KRSRKESYSV YVYKVLKQVH PDTGISSKAM
    61  GIMNSFVNDI FERIAGEASR LAHYNKRSTI TSREIQTAVR LLLPGELAKH AVSEGTKAVT
   121  KYTSSK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against H2BC15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
2.1 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 2.1 nTPM
  • spinal cord: 1.6 nTPM
  • bone marrow: 1.1 nTPM
  • skeletal muscle: 1 nTPM
  • adrenal gland: 0.9 nTPM
  • pancreas: 0.9 nTPM

Single-cell type

  • platelets: 106 nCPM
  • monocyte progenitors: 88 nCPM
  • erythrocyte progenitors: 77 nCPM
  • megakaryocyte progenitors: 70 nCPM
  • megakaryocyte-erythroid progenitors: 66 nCPM
  • plasma cells: 62 nCPM

Immune cell

  • neutrophil: 17 nTPM
  • memory B-cell: 7.7 nTPM
  • plasmacytoid DC: 7 nTPM
  • myeloid DC: 6.2 nTPM
  • naive B-cell: 4.9 nTPM
  • T-reg: 3.5 nTPM

Brain region

  • cerebral cortex: 38 nTPM
  • cerebellum: 33 nTPM
  • basal ganglia: 26 nTPM
  • white matter: 23 nTPM
  • hypothalamus: 19 nTPM
  • midbrain: 18 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about H2BC15.

Disease | ImmuneIEDB

Conditions an epitope on H2BC15 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.94
gnomAD pLI
0
DepMap mean gene effect
-0.98
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads H2BC15 as an antibody target. Whether an autoantibody or antibody against H2BC15 could matter depends on whether native H2BC15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

H2BC15 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label H2BC15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/H2BC15. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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