Seroatlas · Human Serome Atlas

H2AC14

Histone H2A type 1-J

Also known as: H2A/E, H2A1J_HUMAN, H2AFE, HIST1H2AJ

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q99878
Gene
H2AC14
Ensembl
ENSG00000276368
Chromosome
6
Canonical length
128 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]

Canonical amino-acid sequenceUniProt

128 residues, UniProt reviewed canonical sequence.

>Q99878|H2AC14
     1  MSGRGKQGGK ARAKAKTRSS RAGLQFPVGR VHRLLRKGNY AERVGAGAPV YLAAVLEYLT
    61  AEILELAGNA ARDNKKTRII PRHLQLAIRN DEELNKLLGK VTIAQGGVLP NIQAVLLPKK
   121  TESHHKTK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against H2AC14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
6.9 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 6.9 nTPM
  • thymus: 1.6 nTPM
  • lymph node: 0.7 nTPM
  • spleen: 0.7 nTPM
  • esophagus: 0.5 nTPM
  • appendix: 0.3 nTPM

Single-cell type

  • erythrocyte progenitors: 537 nCPM
  • megakaryocyte progenitors: 227 nCPM
  • monocyte progenitors: 193 nCPM
  • erythrocytes: 119 nCPM
  • plasma cells: 56 nCPM
  • neutrophil progenitors: 29 nCPM

Immune cell

  • T-reg: 2.8 nTPM
  • total PBMC: 1.7 nTPM
  • memory CD8 T-cell: 1.3 nTPM
  • naive B-cell: 1.3 nTPM
  • memory CD4 T-cell: 1.2 nTPM
  • neutrophil: 1.2 nTPM

Brain region

  • pons: 3.7 nTPM
  • thalamus: 3.1 nTPM
  • white matter: 2.7 nTPM
  • medulla oblongata: 2.3 nTPM
  • cerebral cortex: 2.1 nTPM
  • cerebellum: 1.8 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about H2AC14.

Disease | ImmuneIEDB

Conditions an epitope on H2AC14 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.89
gnomAD pLI
0.02

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of H2AC14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads H2AC14 as an antibody target. Whether an autoantibody or antibody against H2AC14 could matter depends on whether native H2AC14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

H2AC14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label H2AC14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/H2AC14. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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