Seroatlas · Human Serome Atlas

H2BC4

Histone H2B type 1-C/E/F/G/I

Also known as: H2B.1, H2B.1A, H2B.h, H2B/a, H2B/g, H2B/h, H2B/k, H2B/l, H2B1C_HUMAN, H2BC10, H2BC6, H2BC7, H2BC8, H2BFA, H2BFG, H2BFH, H2BFK, H2BFL, HIST1H2BC, HIST1H2BE, HIST1H2BF, HIST1H2BG, HIST1H2BI

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P62807
Gene: H2BC4
Ensembl: ENSG00000180596
Chromosome: 6
Canonical length: 126 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. The protein has antibacterial and antifungal antimicrobial activity. The main transcript variant of this gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. This transcript variant lacks a polyA tail but instead contains a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Apr 2020]

Canonical amino-acid sequenceUniProt

126 residues, UniProt reviewed canonical sequence.

>P62807|H2BC4
     1  MPEPAKSAPA PKKGSKKAVT KAQKKDGKKR KRSRKESYSV YVYKVLKQVH PDTGISSKAM
    61  GIMNSFVNDI FERIAGEASR LAHYNKRSTI TSREIQTAVR LLLPGELAKH AVSEGTKAVT
   121  KYTSSK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against H2BC4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 28 nTPM
prostate: 22 nTPM
thymus: 16 nTPM
esophagus: 15 nTPM
skeletal muscle: 15 nTPM
liver: 13 nTPM

Single-cell type

platelets: 492 nCPM
esophageal apical cells: 306 nCPM
epididymal principal cells: 143 nCPM
neutrophils: 116 nCPM
plasma cells: 114 nCPM
prostatic club cells: 90 nCPM

Immune cell

neutrophil: 1,084 nTPM
basophil: 61 nTPM
eosinophil: 59 nTPM
naive B-cell: 44 nTPM
plasmacytoid DC: 26 nTPM
memory B-cell: 24 nTPM

Brain region

white matter: 191 nTPM
spinal cord: 170 nTPM
medulla oblongata: 167 nTPM
basal ganglia: 159 nTPM
hypothalamus: 156 nTPM
pons: 150 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about H2BC4.

Disease | ImmuneIEDB

Conditions an epitope on H2BC4 was assayed in.

systemic lupus erythematosus B and T cell
rheumatoid arthritis B and T cell
juvenile ankylosing spondylitis B cell
systemic juvenile rheumatoid arthritis B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.92
gnomAD pLI: 0
DepMap mean gene effect: -1.52
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of H2BC4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

VRK1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads H2BC4 as an antibody target. Whether an autoantibody or antibody against H2BC4 could matter depends on whether native H2BC4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

H2BC4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label H2BC4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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