Seroatlas · Human Serome Atlas

H2BW1

Histone H2B type W-T

Also known as: H2BFWT, H2BWT_HUMAN, TH2B-175

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7Z2G1
Gene
H2BW1
Ensembl
ENSG00000123569
Chromosome
X
Canonical length
153 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-independent histone that is a member of the H2B histone family that is specifically expressed in sperm nuclei. A polymorphism in the 5' UTR of this gene is associated with male infertility.[provided by RefSeq, Oct 2015]

Canonical amino-acid sequenceUniProt

153 residues, UniProt reviewed canonical sequence.

>Q7Z2G1|H2BW1
     1  MATASAMAGP SSETTSEEQL ITQEPKEANS TTSQKQSKQR KRGRHGPRRC HSNCRGDSFA
    61  TYFRRVLKQV HQGLSLSREA VSVMDSLVHD ILDRIATEAG HLARSTKRQT ITAWETRMAV
   121  RLLLPGQMGK LAESEGTKAV LRTSLYAIQQ QRK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against H2BW1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
0.5 nTPM

Expression across tissuesHPA

Tissue

  • testis: 0.5 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM
  • basal ganglia: 0 nTPM

Single-cell type

  • early primary spermatocytes: 6.9 nCPM
  • differentiating spermatogonia: 3.2 nCPM
  • undifferentiated spermatogonia: 0.9 nCPM
  • cytotrophoblasts: 0.4 nCPM
  • migrating cytotrophoblasts: 0.2 nCPM
  • fibro-adipogenic progenitors: 0.1 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 0.5 nTPM
  • hippocampal formation: 0.2 nTPM
  • amygdala: 0.1 nTPM
  • basal ganglia: 0.1 nTPM
  • white matter: 0.1 nTPM
  • cerebellum: 0 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about H2BW1.

Disease | ImmuneIEDB

Conditions an epitope on H2BW1 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.74
gnomAD pLI
0
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads H2BW1 as an antibody target. Whether an autoantibody or antibody against H2BW1 could matter depends on whether native H2BW1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

H2BW1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label H2BW1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/H2BW1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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