Seroatlas · Human Serome Atlas

H2BC12

Histone H2B type 1-K

Also known as: H2B1K_HUMAN, H2BFAiii, H2BFT, HIST1H2BK

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O60814
Gene
H2BC12
Ensembl
ENSG00000197903
Chromosome
6
Canonical length
126 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family. The protein encoded is an antimicrobial protein with antibacterial and antifungal activity. Two transcripts that encode the same protein have been identified for this gene, which is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq, Aug 2015]

Canonical amino-acid sequenceUniProt

126 residues, UniProt reviewed canonical sequence.

>O60814|H2BC12
     1  MPEPAKSAPA PKKGSKKAVT KAQKKDGKKR KRSRKESYSV YVYKVLKQVH PDTGISSKAM
    61  GIMNSFVNDI FERIAGEASR LAHYNKRSTI TSREIQTAVR LLLPGELAKH AVSEGTKAVT
   121  KYTSAK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against H2BC12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
90 nTPM

Expression across tissuesHPA

Tissue

  • prostate: 90 nTPM
  • liver: 86 nTPM
  • thymus: 82 nTPM
  • fallopian tube: 72 nTPM
  • lymph node: 72 nTPM
  • esophagus: 70 nTPM

Single-cell type

  • tuft cells: 58 nCPM
  • erythrocyte progenitors: 42 nCPM
  • platelets: 32 nCPM
  • monocyte progenitors: 26 nCPM
  • megakaryocytes: 25 nCPM
  • megakaryocyte progenitors: 22 nCPM

Immune cell

  • eosinophil: 367 nTPM
  • neutrophil: 344 nTPM
  • basophil: 270 nTPM
  • naive B-cell: 154 nTPM
  • plasmacytoid DC: 134 nTPM
  • memory B-cell: 121 nTPM

Brain region

  • white matter: 62 nTPM
  • spinal cord: 48 nTPM
  • choroid plexus: 47 nTPM
  • medulla oblongata: 43 nTPM
  • basal ganglia: 42 nTPM
  • cerebral cortex: 41 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about H2BC12.

Disease | ImmuneIEDB

Conditions an epitope on H2BC12 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.97
gnomAD pLI
0

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of H2BC12 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads H2BC12 as an antibody target. Whether an autoantibody or antibody against H2BC12 could matter depends on whether native H2BC12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

H2BC12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label H2BC12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/H2BC12. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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