Seroatlas · Human Serome Atlas

H2AC18

Histone H2A type 2-A

Also known as: H2A.2, H2A/q, H2A/r, H2A2A_HUMAN, H2AC19, H2AFO, HIST2H2AA, HIST2H2AA3, HIST2H2AA4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6FI13
Gene: H2AC18
Ensembl: ENSG00000288825
Chromosome: 1
Canonical length: 130 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy. [provided by RefSeq, Aug 2015]

Canonical amino-acid sequenceUniProt

130 residues, UniProt reviewed canonical sequence.

>Q6FI13|H2AC18
     1  MSGRGKQGGK ARAKAKSRSS RAGLQFPVGR VHRLLRKGNY AERVGAGAPV YMAAVLEYLT
    61  AEILELAGNA ARDNKKTRII PRHLQLAIRN DEELNKLLGK VTIAQGGVLP NIQAVLLPKK
   121  TESHHKAKGK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against H2AC18 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 82 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 82 nTPM
prostate: 55 nTPM
liver: 21 nTPM
cervix: 20 nTPM
salivary gland: 17 nTPM
skeletal muscle: 16 nTPM

Single-cell type

platelets: 1.4 nCPM
basal prostatic cells: 0.6 nCPM
early spermatids: 0.1 nCPM
late primary spermatocytes: 0.1 nCPM
migrating cytotrophoblasts: 0.1 nCPM
neutrophils: 0.1 nCPM

Immune cell

basophil: 238 nTPM
eosinophil: 55 nTPM
memory B-cell: 34 nTPM
T-reg: 24 nTPM
NK-cell: 18 nTPM
non-classical monocyte: 11 nTPM

Brain region

choroid plexus: 89 nTPM
pons: 24 nTPM
thalamus: 2.9 nTPM
medulla oblongata: 0.2 nTPM
midbrain: 0.1 nTPM
amygdala: 0 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about H2AC18.

Disease | ImmuneIEDB

Conditions an epitope on H2AC18 was assayed in.

rheumatoid arthritis B cell
systemic lupus erythematosus B cell

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

heterochromatin formation

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads H2AC18 as an antibody target. Whether an autoantibody or antibody against H2AC18 could matter depends on whether native H2AC18 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

H2AC18 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label H2AC18 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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