Seroatlas · Human Serome Atlas

H2AZ2

Histone H2A.V

Also known as: H2AFV, H2AV, H2AV_HUMAN, MGC10170, MGC10831, MGC1947

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q71UI9
Gene: H2AZ2
Ensembl: ENSG00000105968
Chromosome: 7
Canonical length: 128 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. Several transcript variants encoding different isoforms, have been identified for this gene. [provided by RefSeq, Oct 2015]

Canonical amino-acid sequenceUniProt

128 residues, UniProt reviewed canonical sequence.

>Q71UI9|H2AZ2
     1  MAGGKAGKDS GKAKAKAVSR SQRAGLQFPV GRIHRHLKTR TTSHGRVGAT AAVYSAAILE
    61  YLTAEVLELA GNASKDLKVK RITPRHLQLA IRGDEELDSL IKATIAGGGV IPHIHKSLIG
   121  KKGQQKTA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against H2AZ2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 298 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 298 nTPM
thymus: 268 nTPM
tonsil: 159 nTPM
lymph node: 135 nTPM
retina: 131 nTPM
heart muscle: 130 nTPM

Single-cell type

early spermatids: 652 nCPM
extravillous trophoblasts: 543 nCPM
monocyte progenitors: 514 nCPM
neutrophil progenitors: 429 nCPM
late primary spermatocytes: 402 nCPM
gastric progenitor cells: 382 nCPM

Immune cell

eosinophil: 230 nTPM
T-reg: 169 nTPM
plasmacytoid DC: 147 nTPM
basophil: 104 nTPM
myeloid DC: 96 nTPM
memory CD4 T-cell: 87 nTPM

Brain region

cerebellum: 164 nTPM
thalamus: 159 nTPM
spinal cord: 145 nTPM
basal ganglia: 144 nTPM
midbrain: 144 nTPM
white matter: 141 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.82
gnomAD pLI: 0.47
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads H2AZ2 as an antibody target. Whether an autoantibody or antibody against H2AZ2 could matter depends on whether native H2AZ2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

H2AZ2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label H2AZ2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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