Seroatlas · Human Serome Atlas

H2BC14

Histone H2B type 1-M

Also known as: dJ160A22.3, H2B/e, H2B1M_HUMAN, H2BFE, HIST1H2BM

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q99879
Gene: H2BC14
Ensembl: ENSG00000273703
Chromosome: 6
Canonical length: 126 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]

Canonical amino-acid sequenceUniProt

126 residues, UniProt reviewed canonical sequence.

>Q99879|H2BC14
     1  MPEPVKSAPV PKKGSKKAIN KAQKKDGKKR KRSRKESYSV YVYKVLKQVH PDTGISSKAM
    61  GIMNSFVNDI FERIAGEASR LAHYNKRSTI TSREIQTAVR LLLPGELAKH AVSEGTKAVT
   121  KYTSSK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against H2BC14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 3.3 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 3.3 nTPM
thymus: 2.9 nTPM
choroid plexus: 1.9 nTPM
lymph node: 1.3 nTPM
tonsil: 1 nTPM
cervix: 0.9 nTPM

Single-cell type

erythrocyte progenitors: 37 nCPM
megakaryocyte progenitors: 16 nCPM
monocyte progenitors: 15 nCPM
tuft cells: 12 nCPM
erythrocytes: 8.9 nCPM
plasma cells: 4.2 nCPM

Immune cell

MAIT T-cell: 0.4 nTPM
memory CD4 T-cell: 0.4 nTPM
naive B-cell: 0.4 nTPM
memory B-cell: 0.3 nTPM
memory CD8 T-cell: 0.3 nTPM
NK-cell: 0.3 nTPM

Brain region

white matter: 6.7 nTPM
cerebellum: 5.8 nTPM
midbrain: 5.7 nTPM
cerebral cortex: 4.9 nTPM
spinal cord: 4.7 nTPM
basal ganglia: 4.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.97
gnomAD pLI: 0
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

nucleosome assembly

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads H2BC14 as an antibody target. Whether an autoantibody or antibody against H2BC14 could matter depends on whether native H2BC14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

H2BC14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label H2BC14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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