Seroatlas · Human Serome Atlas

MACROH2A2

Core histone macro-H2A.2

Also known as: H2AFY2, H2AW_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P0M6
Gene: MACROH2A2
Ensembl: ENSG00000099284
Chromosome: 10
Canonical length: 372 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and may participate in stable X chromosome inactivation. [provided by RefSeq, Oct 2015]

Canonical amino-acid sequenceUniProt

372 residues, UniProt reviewed canonical sequence.

>Q9P0M6|MACROH2A2
     1  MSGRSGKKKM SKLSRSARAG VIFPVGRLMR YLKKGTFKYR ISVGAPVYMA AVIEYLAAEI
    61  LELAGNAARD NKKARIAPRH ILLAVANDEE LNQLLKGVTI ASGGVLPRIH PELLAKKRGT
   121  KGKSETILSP PPEKRGRKAT SGKKGGKKSK AAKPRTSKKS KPKDSDKEGT SNSTSEDGPG
   181  DGFTILSSKS LVLGQKLSLT QSDISHIGSM RVEGIVHPTT AEIDLKEDIG KALEKAGGKE
   241  FLETVKELRK SQGPLEVAEA AVSQSSGLAA KFVIHCHIPQ WGSDKCEEQL EETIKNCLSA
   301  AEDKKLKSVA FPPFPSGRNC FPKQTAAQVT LKAISAHFDD SSASSLKNVY FLLFDSESIG
   361  IYVQEMAKLD AK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MACROH2A2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

endometrium: 18 nTPM
ovary: 17 nTPM
cerebellum: 16 nTPM
esophagus: 16 nTPM
fallopian tube: 16 nTPM
cervix: 15 nTPM

Single-cell type

adipocytes: 270 nCPM
sertoli cells: 111 nCPM
granulosa cells: 93 nCPM
epididymal efferent duct absorptive cells: 68 nCPM
myonuclei: 67 nCPM
thyrotrophs: 57 nCPM

Immune cell

myeloid DC: 13 nTPM
intermediate monocyte: 5.4 nTPM
non-classical monocyte: 3 nTPM
classical monocyte: 2.4 nTPM
total PBMC: 1.5 nTPM
basophil: 1 nTPM

Brain region

cerebellum: 12 nTPM
hypothalamus: 8 nTPM
basal ganglia: 7.9 nTPM
cerebral cortex: 6.6 nTPM
amygdala: 6.1 nTPM
hippocampal formation: 5.8 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MACROH2A2.

Disease | ImmuneIEDB

Conditions an epitope on MACROH2A2 was assayed in.

rheumatoid arthritis B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.3
gnomAD pLI: 0.98
DepMap mean gene effect: -0.18
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MACROH2A2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SSRP1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MACROH2A2 as an antibody target. Whether an autoantibody or antibody against MACROH2A2 could matter depends on whether native MACROH2A2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MACROH2A2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MACROH2A2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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