Seroatlas · Human Serome Atlas

H3Y2

Histone H3.X

Also known as: H3.X, H3.Y.2, H3Y2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0DPK5
Gene
H3Y2
Ensembl
ENSG00000268799
Chromosome
5
Canonical length
147 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Acrosome,Principal piece

OverviewNCBI Gene

Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be a structural constituent of chromatin. Located in nucleoplasm. Part of nucleosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

147 residues, UniProt reviewed canonical sequence.

>P0DPK5|H3Y2
     1  MARTKQTARK ATAWQAPRKP LATKAARKRA SPTGGIKKPH RYKPGTLALR EIRKYQKSTQ
    61  LLLRKLPFQR LVREIAQAIS PDLRFQSAAI GALQEASEAY LVQLFEDTNL CAIHARRVTI
   121  MPRDMQLARR LRGEGAGEPT LLGNLAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against H3Y2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
0.3 nTPM

Expression across tissuesHPA

Tissue

  • testis: 0.3 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM
  • basal ganglia: 0 nTPM

Single-cell type

  • early spermatids: 9.6 nCPM
  • late spermatids: 3.3 nCPM
  • undifferentiated spermatogonia: 2.5 nCPM
  • sertoli cells: 1.1 nCPM
  • differentiating spermatogonia: 0.2 nCPM
  • early primary spermatocytes: 0.2 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 0.3 nTPM
  • basal ganglia: 0.1 nTPM
  • hippocampal formation: 0.1 nTPM
  • white matter: 0.1 nTPM
  • amygdala: 0 nTPM
  • cerebellum: 0 nTPM

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads H3Y2 as an antibody target. Whether an autoantibody or antibody against H3Y2 could matter depends on whether native H3Y2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

H3Y2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label H3Y2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/H3Y2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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